تقرير
Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: Integrating viscous modeling and experimental approaches.
| العنوان: | Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: Integrating viscous modeling and experimental approaches. |
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| المؤلفون: | Romanos, Michèle, Salisbury, Tasha, Stephan, Samuel, Lansford, Rusty, Degond, Pierre, Trescases, Ariane, Bénazéraf, Bertrand |
| المساهمون: | Institut Camille Jordan (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Modélisation mathématique, calcul scientifique (MMCS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Children’s Hospital Los Angeles Los Angeles, Unité de biologie Moléculaire, Cellulaire et du Développement (MCD), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Financial support for this project was provided by the CNRS through the 80|Prime program (S.S/B.B), Ph.D. Fellowship funded by Toulouse University the Occitanie Region and the FRM (4th year) (M. Romanos). |
| المصدر: | https://hal.science/hal-04483549Test ; 2024. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2024 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Developmental biology, continuum modeling, axial elongation, inter-tissue mechanics, bird embryo, morphogenesis, [SDV]Life Sciences [q-bio], [MATH]Mathematics [math] |
| الوصف: | The study of how mechanical interactions and different cellular behaviors affect tissues and embryo shaping has been and remains an important challenge in biology. Axial extension is a morphogenetic process that results in the acquisition of the elongated shape of the vertebrate embryonic body. Several adjacent tissues are involved in the process, including the tissues that form the spinal cord and musculoskeletal system: the neural tube and the paraxial mesoderm, respectively. Although we have a growing understanding of how each of these tissues elongates, we still need to fully understand the morphogenetic consequences of their growth and mechanical interactions. In this study, we develop a 2D multi-tissue continuum-based mathematical model to simulate and study how differential growth, tissue biophysical properties, and mechanical interactions affect the morphogenesis of the embryonic body during axial extension. Our model captures the long-term dynamics of embryonic posterior tissues previously observed in vivo by time-lapse imaging of bird embryos. It reveals the underestimated influence of differential tissue proliferation rates in inter-tissue interaction and shaping by capturing the relative impact of this process on tissue dynamics. We verified the predictions of our model in quail embryos by showing that decreasing the rate of cell proliferation in the paraxial mesoderm affects long-term tissue dynamics and shaping of both the paraxial mesoderm and the neighboring neural tube. Overall, our work provides a new theoretical platform to consider the long-term consequences of tissue differential growth and mechanical interactions on morphogenesis. |
| نوع الوثيقة: | report |
| اللغة: | English |
| العلاقة: | hal-04483549; https://hal.science/hal-04483549Test; https://hal.science/hal-04483549/documentTest; https://hal.science/hal-04483549/file/Romanos%20et%20al%202024%20Manuscript%20and%20Figures.pdfTest; BIORXIV: 2024.02.26.581143 |
| DOI: | 10.1101/2024.02.26.581143 |
| الإتاحة: | https://doi.org/10.1101/2024.02.26.581143Test https://hal.science/hal-04483549Test https://hal.science/hal-04483549/documentTest https://hal.science/hal-04483549/file/Romanos%20et%20al%202024%20Manuscript%20and%20Figures.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.5744D808 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1101/2024.02.26.581143 |
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