دورية أكاديمية
Erythropoietin protects hippocampal neurons following status epilepticus
| العنوان: | Erythropoietin protects hippocampal neurons following status epilepticus |
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| المؤلفون: | Nadam, Jérémie, Navarro, Fabrice, Sanchez, Pascal, Moulin, Colette, Georges, Béatrice, Laglaine, Aël, Pequignot, Jean-Marc, Morales, Anne, Ryvlin, Philippe, Bezin, Laurent |
| المساهمون: | Physiologie intégrative, cellulaire et moléculaire (PICM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Activation et dysfonctionnements des réseaux neuronaux (EA1880), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0969-9961. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2007 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | astrocytes, erythropoietin receptor, hypoxia-inducible factor-1, aHIF, pilocarpine, status epilepticus, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] |
| الوصف: | International audience ; Objective: Neuroprotective functions of brain-derived erythropoietin (Epo) are thought to involve both Epo receptor (Epo-R) and common β chain (βc). Here, we measured the response of Epo system (Epo, Epo-R and βc) during neurodegenerative processes occurring following status epilepticus (SE), and examined whether recombinant human Epo (rHuEpo) could support neuronal survival. Methods: We analyzed Epo, Epo-R and βc expression at both messenger RNA and protein levels after pilocarpine-induced SE (Pilo-SE) in the adult rat hippocampus. Potential protective effect of rHuEpo (Eprex®, Janssen-Cilag; 5,000 IU/kg) was investigated 2 weeks after SE. Results: By contrast to Epo and βc, detected in few neurons only in the hippocampus, Epo-R is expressed by a majority of neurons. Following Pilo-SE, Epo is induced in numerous astrocytes and hippocampal areas where astroglial induction of Epo is the greatest exhibit a pattern of delayed neuronal death. βc is induced in reactive microglia only. Therapeutic administration of rHuEpo reduces considerably neuronal degeneration in the hippocampus. Interpretation: rHuEpo may support astroglial Epo to promote hippocampus neuronal survival following SE, likely through a mechanism involving Epo-R mainly. Paucity of βc in the hippocampus rules out the possibility that βc can play a major role in rHuEpo neuroprotective effects following SE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-00018753; https://hal.science/hal-00018753Test; https://hal.science/hal-00018753v4/documentTest; https://hal.science/hal-00018753v4/file/Nadam_060721_HAL.pdfTest |
| DOI: | 10.1016/j.nbd.2006.10.009 |
| الإتاحة: | https://doi.org/10.1016/j.nbd.2006.10.009Test https://hal.science/hal-00018753Test https://hal.science/hal-00018753v4/documentTest https://hal.science/hal-00018753v4/file/Nadam_060721_HAL.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CE3C77B2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.nbd.2006.10.009 |
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