دورية أكاديمية
How can we measure insulin sensitivity/resistance?
| العنوان: | How can we measure insulin sensitivity/resistance? |
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| المؤلفون: | Antuna-Puente, B., Disse, E., Rabasa-Lhoret, R., Laville, Martine, Capeau, J., Bastard, J. -P. |
| المساهمون: | Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon (COMUE), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL), Université de Montréal (UdeM), Mécanisme Moléculaire du Diabète (MMD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Consejo Nacional de Ciencia y Tecnologia (CONACyT), Fonds de recherche en sante du Quebec (FRSQ), Canadian Institute for Health Research (CHIR), MONET-SOMET programmes, EU QLG1-CT-2001-01252 |
| المصدر: | ISSN: 1262-3636. |
| بيانات النشر: | HAL CCSD Elsevier Masson |
| سنة النشر: | 2011 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Hyperinsulinaemic-euglycaemic glucose clamp, Insulin sensitivity, Insulin resistance, OGTT, Review, GLUCOSE-TOLERANCE TEST, HOMEOSTASIS MODEL ASSESSMENT, HYPERINSULINEMIC-EUGLYCEMIC CLAMP, CARDIOVASCULAR RISK-FACTORS, OBESE POSTMENOPAUSAL WOMEN, CHECK INDEX, DIABETES-MELLITUS, CLINICAL-PRACTICE, HOMA, QUICKI, MINIMAL MODEL, INTRAVENOUS GLUCOSE, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Insulin resistance represents a major public health problem, as it plays a major role in the pathophysiology of type 2 diabetes mellitus; it is also associated with increased cardiovascular risk and atherogenic dyslipidaemia, and is a central component of the cluster of metabolic abnormalities that comprise the metabolic syndrome. Thus, the development of tools to quantify insulin sensitivity/resistance has been the main objective of a number of studies. Insulin resistance can be estimated with the use of several biological measurements that evaluate different aspects of this complex situation. To that end, it requires various resources, ranging from just a single fasting blood sample for simple indices, such as the HOMA or QUICKI, to a research setting in which to perform the gold-standard hyperinsulinaemic-euglycaemic clamp test. The choice of method for evaluating insulin resistance depends on the nature of the information required (classification of individual subjects, group comparisons, precise measurement of either global, muscle or liver insulin sensitivity/resistance) and on the available resources. The aim of this review is to analyze the most frequently used assay methods in an attempt to evaluate when and why these methods may be useful. (C) 2011 Elsevier Masson SAS. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-292522-8 0-00-292522-2 |
| العلاقة: | hal-02650886; https://hal.inrae.fr/hal-02650886Test; PRODINRA: 202858; WOS: 000292522200002 |
| DOI: | 10.1016/j.diabet.2011.01.002 |
| الإتاحة: | https://doi.org/10.1016/j.diabet.2011.01.002Test https://hal.inrae.fr/hal-02650886Test |
| رقم الانضمام: | edsbas.382289A5 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780002925228 0002925222 |
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| DOI: | 10.1016/j.diabet.2011.01.002 |