دورية أكاديمية
Leptomeningeal enhancement on post-contrast FLAIR images for early diagnosis of Susac syndrome
| العنوان: | Leptomeningeal enhancement on post-contrast FLAIR images for early diagnosis of Susac syndrome |
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| المؤلفون: | Bellanger, G., Biotti, Damien, Adam, G., Darcourt, J., Roques, Margaux, Patsoura, S., Savatovsky, J., Obadia, M., Menjot de Champfleur, Nicolas, Charif, M., Labauge, Pierre, Cotton, F., Durand-Dubief, Françoise, Tourdias, Thomas, Dulau, C., Kremer, S., de Sèze, J., Ciron, Jonathan, Varenne, Fanny, Viguier, Alain, Lerebours, F., Larrue, V., Cognard, C., Bonneville, Fabrice |
| المساهمون: | Service Neuroradiologie Diagnostique et Thérapeutique CHU Toulouse, Pôle imagerie médicale CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Département Neurologie CHU Toulouse, Pôle Neurosciences CHU Toulouse, Fondation Ophtalmologique Adolphe de Rothschild Paris, Neuroradiologie Hôpital Gui de Chauliac, Hôpital Gui de Chauliac CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon, Departement de Neurologie (HCL), Département de Neuro-Radiologie Bordeaux (DNR - Bordeaux), CHU Bordeaux, Service de Neurologie Strasbourg, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Nouvel Hôpital Civil de Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS), Département de Neuroradiologie Strasbourg, Service de neurologie Bordeaux, CHU Bordeaux-Groupe hospitalier Pellegrin, Service d'Ophtalmologie CHU Toulouse, Pôle Céphalique CHU Toulouse |
| المصدر: | ISSN: 1352-4585. |
| بيانات النشر: | HAL CCSD SAGE Publications |
| سنة النشر: | 2022 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Multiples sclerosis, Susac syndrome, leptomeningeal enhancement, post-contrast FLAIR, MESH: Contrast Media, MESH: Early Diagnosis, MESH: Humans, MESH: Magnetic Resonance Imaging / methods, MESH: Retrospective Studies, MESH: Susac Syndrome* / diagnostic imaging, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Background: Leptomeningeal enhancement (LME) is a key feature of Susac syndrome (SuS) but is only occasionally depicted on post-contrast T1-weighted images (T1-WI).Objective: As post-contrast fluid-attenuated inversion recovery (FLAIR) may be more sensitive, our aim was to assess LME in SuS on this sequence.Methods: From 2010 to 2020, 20 patients with definite SuS diagnosis were retrospectively enrolled in this multicentre study. Two radiologists independently assessed the number of LME on post-contrast FLAIR and T1-WI acquisitions performed before any treatment. A chi-square test was used to compare both sequences and the interrater agreement was calculated.Results: Thirty-five magnetic resonance imagings (MRIs) were performed before treatment, including 19 post-contrast FLAIR images in 17 patients and 25 post-contrast T1-WI in 19 patients. In terms of patients, LME was observed on all post-contrast FLAIR, contrary to post-contrast T1-WI (17/17 (100%) vs. 15/19 (79%), p < 0.05). In terms of sequences, LME was observed on all post-contrast FLAIR, contrary to post-contrast T1-WI (19/19 (100%) vs. 16/25 (64%), p < 0.005). LME was disseminated at both supratentorial (19/19) and infratentorial (18/19) levels on post-contrast FLAIR, contrary to post-contrast T1-WI (3/25 and 9/25, respectively). Interrater agreement was excellent for post-contrast FLAIR (κ = 0.95) but only moderate for post-contrast T1-WI (κ = 0.61).Conclusion: LME was always observed and easily visible on post-contrast FLAIR images prior to SuS treatment. In association with other MRI features, it is highly indicative of SuS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33988466; hal-03711957; https://hal.science/hal-03711957Test; PUBMED: 33988466 |
| DOI: | 10.1177/13524585211012349 |
| الإتاحة: | https://doi.org/10.1177/13524585211012349Test https://hal.science/hal-03711957Test |
| حقوق: | http://hal.archives-ouvertes.fr/licences/copyrightTest/ |
| رقم الانضمام: | edsbas.1228F194 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/13524585211012349 |
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