دورية أكاديمية
Sulfur source-mediated in situ growth of highly conductive nanocomposites for sensitive detection of miRNA-21
| العنوان: | Sulfur source-mediated in situ growth of highly conductive nanocomposites for sensitive detection of miRNA-21 |
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| المؤلفون: | Fu, Sinan, Ning, Zhizhi, Li, Qiuyue, He, Yutao, Xie, Chang, Cheng, Jing, Ye, Huarong, Li, Qian, Jaffrezic-Renault, Nicole, Feng, Jialu, Guo, Zhenzhong |
| المساهمون: | School of Pubic Health, Wuhan University of Science and Technology, Huazhong University of Science and Technology Wuhan (HUST), Hubei Prov Key Lab Occupat Hazard Identificat & C, Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan (Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan), Sch Publ Hlth, Med Coll, Wuhan University of Science & Technology, China Resources & Wisco Gen Hosp, Hubei University, ISA-Micro & Nanobiotechnologies, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0925-4005 ; EISSN: 1873-3077. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Co9S8@WS2/DWCNT-AgNPs, In situ growth, biosensor, miRNA-21, [CHIM.ANAL]Chemical Sciences/Analytical chemistry |
| الوصف: | International audience ; The accurate detection of miRNA-21, one of the emerging biomarkers for breast cancer, is extremely important for facilitating early diagnosis. In this paper, we present a novel nanocomposite material Co9S8@WS2/DWCNT was prepared through a one-pot hydrothermal method. WS2 (Tungsten disulfide) semiconductor nanosheets were used as negative carriers to provide binding sites. TAA (Thioacetamide) was used as a sulfur source and crosslinking agent to modify ZIF-67 (Co-based zeolite imidazole framework) into Co9S8 with excellent electrical conductivity and to grow it in situ on the WS2 surface. DWCNT (Double-walled carbon nanotubes) was then stacked with WS2 by π-π conjugation. To further enhance the electrical conductivity and biocompatibility of the composite nanomaterials, it was doped by AgNPs (Silver nanoparticles) to obtain Co9S8@WS2/DWCNT-AgNPs nanocomposites with excellent electrochemical properties. The capture probe cDNA was immobilized on the electrode through Ag-S bonding to enable sensitive detection of miRNA-21. With a concentration response range of 10^-18 M - 10^-11 M and a detection limit as low as 1.54 aM, the detection of miRNA-21 in human serum samples has been successfully achieved applying to this biosensing platform. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04497322; https://hal.science/hal-04497322Test |
| DOI: | 10.1016/j.snb.2023.134086 |
| الإتاحة: | https://doi.org/10.1016/j.snb.2023.134086Test https://hal.science/hal-04497322Test |
| رقم الانضمام: | edsbas.CCDCD437 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.snb.2023.134086 |
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