دورية أكاديمية
Anti-Donor HLA Antibody Response After Pancreatic Islet Grafting: Characteristics, Risk Factors, and Impact on Graft Function
| العنوان: | Anti-Donor HLA Antibody Response After Pancreatic Islet Grafting: Characteristics, Risk Factors, and Impact on Graft Function |
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| المؤلفون: | Pouliquen, Eric, Baltzinger, P., Lemle, A., Chen, Chien-Chia, Parissiadis, A., Borot, S., Frimat, L., Girerd, S., Berney, T., Lablanche, S., Benhamou, P. Y., Morelon, E., Badet, L., Dubois, V., Kessler, L., Thaunat, Olivier, Network, Gragil |
| المساهمون: | Service de Transplantation, Néphrologie et Immunologie Clinique Hôpital Edouard Herriot, HCL, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL), Lymphocytes B effecteurs et à mémoire – Effector and memory B cells, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Endocrinologie - Diabète et Maladies Métaboliques, Les Hôpitaux Universitaires de Strasbourg (HUS), Etablissement Français du Sang - Grand Est (EFS - alsace strasbourg), Service de Diabétologie - Endocrinologie CHRU Besançon, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service de Néphrologie CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Department of Surgery, Université de Genève = University of Geneva (UNIGE), Service d'Endocrinologie, Pôle Digidune, Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Service d'Urologie et Chirurgie de la Transplantation, Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Etablissement français du sang- Rhône-Alpes Lyon |
| المصدر: | ISSN: 1600-6135. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Middle Aged, Postoperative Complications, Male, Longitudinal Studies, Adult, alloantibody, clinical research/practice, Diabetes Mellitus, Type 1, Female, Follow-Up Studies, Graft Rejection, Graft Survival, HLA Antigens, Humans, islet transplantation, Islets of Langerhans Transplantation, Isoantibodies, Transplant Recipients, Tissue Donors, Risk Factors, Retrospective Studies, rejection: antibody-mediated (ABMR), Prognosis, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; Pancreatic islet grafting restores endogenous insulin production in type 1 diabetic patients, but long-term outcomes remain disappointing as a result of immunological destruction of allogeneic islets. In solid organ transplantation, donor-specific anti-HLA antibodies (DSA) are the first cause of organ failure. This retrospective multicentric study aimed at providing in-depth characterization of DSA response after pancreatic islet grafting, identifying the risk factor for DSA generation and determining the impact of DSA on graft function. Forty-two pancreatic islet graft recipients from the Groupe Rhin-Rhône-Alpes-Genève pour la Greffe d'Ilots de Langerhans consortium were enrolled. Pre- and postgrafting sera were screened for the presence of DSA and their ability to activate complement. Prevalence of DSA was 25% at 3 years postgrafting. The risk of sensitization increased steeply after immunosuppressive drug withdrawal. DSA repertoire diversity correlated with the number of HLA and eplet mismatches. DSA titer was significantly lower from that observed in solid organ transplantation. No detected DSA bound the complement fraction C3d. Finally, in contrast with solid organ transplantation, DSA did not seem to negatively affect pancreatic islet graft survival. This might be due to the low DSA titers, specific features of IgG limiting their ability to activate the complement and/or the lack of allogenic endothelial targets in pancreatic islet grafts. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27343461; hal-01908857; https://hal.science/hal-01908857Test; PUBMED: 27343461 |
| DOI: | 10.1111/ajt.13936 |
| الإتاحة: | https://doi.org/10.1111/ajt.13936Test https://hal.science/hal-01908857Test |
| رقم الانضمام: | edsbas.954CB8EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/ajt.13936 |
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