دورية أكاديمية
Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection
| العنوان: | Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection |
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| المؤلفون: | Reynard, Olivier, Gonzalez, Claudia, Dumont, Claire, Iampietro, Mathieu, Ferren, Marion, Le Guellec, Sandrine, Laurie, Lajoie, Mathieu, Cyrille, Carpentier, Gabrielle, Roseau, Georges, Bovier, Francesca, T, Zhu, Yun, Le Pennec, Deborah, Montharu, Jérome, Addetia, Amin, Greninger, Alexander, L, Alabi, Christopher, A, Brisebard, Elise, Moscona, Anne, Vecellio, Laurent, Porotto, Matteo, Horvat, Branka |
| المساهمون: | Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Tours (UT), DTF-Aerodrug, DTF, Infectiologie et Santé Publique (UMR ISP), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Columbia University College of Physicians and Surgeons, Capital University of Medical Sciences Beijing (CUMS), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Washington Seattle, Cornell University New York, Expertise en Anatomie Pathologique (APEX), Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli, France, Region ARA (Pack Ambition Recherche, project AerVirStop-BH), United States Department of Health & Human Services National Institutes of Health (NIH) - USA (NS09126, NS105699, AI159085), ANR-11-LABX-0048,ECOFECT,Dynamiques eco-évolutives des maladies infectieuses(2011), ANR-11-IDEX-0007,Avenir L.S.E.,PROJET AVENIR LYON SAINT-ETIENNE(2011), ANR-16-ASMA-0008,NebuNipaStop,Nébulisation de peptides anti-viraux pour lutter contre l'infection par le virus Nipah(2016) |
| المصدر: | ISSN: 2041-1723. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2022 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; Measles is the most contagious airborne viral infection and the leading cause of child death among vaccine-preventable diseases. We show here that aerosolized lipopeptide fusion inhibitor, derived from heptad-repeat regions of the measles virus (MeV) fusion protein, blocks respiratory MeV infection in a non-human primate model, the cynomolgus macaque. We use a custom-designed mesh nebulizer to ensure efficient aerosol delivery of peptide to the respiratory tract and demonstrate the absence of adverse effects and lung pathology in macaques. The nebulized peptide efficiently prevents MeV infection, resulting in the complete absence of MeV RNA, MeV-infected cells, and MeV-specific humoral responses in treated animals. This strategy provides an additional means to fight against respiratory infection in non-vaccinated people, that can be readily translated to human trials. It presents a proof-of-concept for the aerosol delivery of fusion inhibitory peptides to protect against measles and other airborne viruses, including SARS-CoV-2, in case of high-risk exposure. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36307480; hal-03886267; https://cnrs.hal.science/hal-03886267Test; https://cnrs.hal.science/hal-03886267/documentTest; https://cnrs.hal.science/hal-03886267/file/2022_Reynard_Nature-Com_vol-13_art-6439.pdfTest; PUBMED: 36307480; PUBMEDCENTRAL: PMC9616412; WOS: 000886265500008 |
| DOI: | 10.1038/s41467-022-33832-6 |
| الإتاحة: | https://doi.org/10.1038/s41467-022-33832-6Test https://cnrs.hal.science/hal-03886267Test https://cnrs.hal.science/hal-03886267/documentTest https://cnrs.hal.science/hal-03886267/file/2022_Reynard_Nature-Com_vol-13_art-6439.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.26F008AC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-022-33832-6 |
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