دورية أكاديمية
Chronic electrostimulation after nerve repair by self-anastomosis: effects on the size, the mechanical, histochemical and biochemical muscle properties
| العنوان: | Chronic electrostimulation after nerve repair by self-anastomosis: effects on the size, the mechanical, histochemical and biochemical muscle properties |
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| المؤلفون: | Marqueste, Tanguy, Decherchi, P., Desplanches, D., Favier, R., Grelot, L., Jammes, Y. |
| المساهمون: | Laboratoire des Déterminants Physiologiques de l'Activité Physique, Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiopathologie Respiratoire (UPRES EA 2201), Université de la Méditerranée - Aix-Marseille 2-Institut Fédératif de Recherches Jean ROCHE (IFR 11)-Faculté de Médecine Nord, Physiologie intégrative, cellulaire et moléculaire (PICM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Bioénergétique fondamentale et appliquée, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0001-6322. |
| بيانات النشر: | HAL CCSD Springer Verlag |
| سنة النشر: | 2006 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Contractile properties, Myosin ATPase, Lactate dehydrogenase, Citrate synthase, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] |
| الوصف: | This study tests the effects of chronic electrostimulation on denervated/reinnervated skeletal muscle in producing an optimal restoration of size and mechanical and histochemical properties. We compared tibialis anterior muscles in four groups of rats: in unoperated control (C) and 10 weeks following nerve lesion with suture (LS) in the absence of electrostimulation and in the presence of muscle stimulation with either a monophasic rectangular current (LSE(m)) or a biphasic modulated current (LSE(b)). The main results were (1) muscle atrophy was reduced in LSE(m) (-26%) while it was absent in LSE(b) groups (-8%); (2) the peak twitch amplitude decreased in LS and LSE(m) but not in LSE(b) groups, whereas the contraction time was shorter; (3) muscle reinnervation was associated with the emergence of type IIC fibers and proportions of types I, IIA and IIB fibers recovered in the superficial portion of LSE(b) muscles; (4) the ratio of oxidative to glycolytic activities decreased in the three groups with nerve injury and repair; however, this decrease was more accentuated in LSE(m) groups. We conclude that muscle electrostimulation following denervation and reinnervation tends to restore size and functional and histochemical properties during reinnervation better than is seen in unstimulated muscle |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-00091577; https://hal.science/hal-00091577Test |
| DOI: | 10.1007/s00401-006-0035-2 |
| الإتاحة: | https://doi.org/10.1007/s00401-006-0035-2Test https://hal.science/hal-00091577Test |
| رقم الانضمام: | edsbas.7D76AFA5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00401-006-0035-2 |
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