دورية أكاديمية
Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney
| العنوان: | Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney |
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| المؤلفون: | Tissandie, E., Guéguen, Y., Lobaccaro, J.M.A., Grandcolas, L., Aigueperse, J., Gourmelon, P., Souidi, M. |
| المساهمون: | Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Université Blaise Pascal - Clermont-Ferrand 2 (UBP) |
| المصدر: | Journal of Steroid Biochemistry and Molecular Biology ; https://hal.science/hal-03002300Test ; Journal of Steroid Biochemistry and Molecular Biology, 2008, 110 (3-5), pp.263-268. ⟨10.1016/j.jsbmb.2007.11.002⟩ |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2008 |
| المجموعة: | HAL Clermont Auvergne (Université Blaise Pascal Clermont-Ferrand / Université d'Auvergne) |
| مصطلحات موضوعية: | calbindin, calcium, cell nucleus receptor, colecalciferol, messenger RNA, retinoid X receptor alpha, uranium, vanilloid receptor 5, vitamin D receptor, animal experiment, animal tissue, article, biological activity, brain, calcium blood level, calcium transport, controlled study, enzyme activity, gene sequence, homeostasis, in vivo study, intestine absorption, kidney, kidney tubule absorption, long term exposure, male, nonhuman, nucleotide sequence, polymerase chain reaction, protein blood level |
| الوصف: | International audience ; An increasing awareness of the radiological impact of the nuclear power industry and other nuclear technologies is observed nowadays on general population. This led to renew interest to assess the health impact of the use of enriched uranium (EU). The aim of this work was to investigate in vivo the effects of a chronic exposure to EU on vitamin D3 metabolism, a hormone essential in mineral and bone homeostasis. Rats were exposed to EU in their drinking water for 9 months at a concentration of 40 mg l-1 (1 mg/rat day). The contamination did not change vitamin D plasma level. Vitamin D receptor (vdr) and retinoid X receptor alpha (rxrα), encoding nuclear receptors involved in the biological activities of vitamin D, showed a lower expression in kidney, while their protein levels were paradoxically increased. Gene expression of vitamin D target genes, epithelial Ca2+ channel 1 (ecac1) and Calbindin-D28k (cabp-d28k), involved in renal calcium transport were decreased. Among the vitamin D target organs examined, these molecular modifications occurred exclusively in the kidney, which confirms that this organ is highly sensitive to uranium exposure. In conclusion, this study showed that a chronic exposure to EU affects both mRNA and protein expressions of renal nuclear receptors involved in vitamin D metabolism, without any modification of the circulating vitamin D. © 2008 Elsevier Ltd. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03002300; https://hal.science/hal-03002300Test |
| DOI: | 10.1016/j.jsbmb.2007.11.002 |
| الإتاحة: | https://doi.org/10.1016/j.jsbmb.2007.11.002Test https://hal.science/hal-03002300Test |
| رقم الانضمام: | edsbas.DD008745 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jsbmb.2007.11.002 |
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