دورية أكاديمية
The acute inflammatory response to copper(II)-doped biphasic calcium phosphates
| العنوان: | The acute inflammatory response to copper(II)-doped biphasic calcium phosphates |
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| المؤلفون: | Thoraval, L., Thiébault, E., Siboni, Renaud, Moniot, Aurélie, Guillaume, C., Jacobs, A., Nedelec, J.-M., Renaudin, G., Descamps, S., Valfort, Olivier, Gangloff, S.C., Braux, J., Marchat, David, Velard, F. |
| المساهمون: | Biomatériaux et inflammation en site osseux - EA 4691 (BIOS), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA), Institut de Chimie de Clermont-Ferrand (ICCF), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT), Laboratoire Georges Friedel (LGF-ENSMSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Etablissement français du sang, Auvergne-Loire Saint-Etienne (EFS), Etablissement Français du Sang, Université de Reims Champagne-Ardenne, EA4691 “Biomatériaux et Inflammation en site osseux” BIOS, Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, INSERM, ANR-21-CE19-0055,PIMyBone,Biocéramiques multi-dopées structurées par PIM pour la régénération des grands défauts osseux(2021) |
| المصدر: | ISSN: 2590-0064 ; Materials Today Bio ; https://hal-emse.ccsd.cnrs.fr/emse-04237635Test ; Materials Today Bio, 2023, 23, pp.100814. ⟨10.1016/j.mtbio.2023.100814⟩ ; https://www.sciencedirect.com/science/article/pii/S2590006423002740Test. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | HAL Clermont Auvergne (Université Blaise Pascal Clermont-Ferrand / Université d'Auvergne) |
| مصطلحات موضوعية: | Biomaterials, Cu-doped biphasic calcium phosphate, Cytokines, NETosis, Inflammation, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering |
| الوصف: | International audience ; Infection and inflammation are two key features to consider to avoid septic or aseptic loosening of bone-implanted biomaterials. In this context, various approaches to fine-tune the biomaterial's properties have been studied in order to modulate the crosstalk between immune and skeletal cells. Cation-doping strategies for tuning of calcium phosphates properties has been evidenced as a promising way to control the biomaterial-induced inflammatory process, and thus improving their osteoimmunomodulatory properties. Copper(II) ions are recognized for their antibacterial potential, but the literature on their impact on particulate material-induced acute inflammation is scarce. We synthesized copper(II) ions-doped biphasic calcium phosphate (BCP), intended to exhibit osteoimmunomodulatory properties. We addressed in vitro, for the first time, the inflammatory response of human primary polymorphonuclear neutrophils (PMNs) to copper(II) ions-doped or undoped (BCP) powders, synthesized by an original and robust wet method, in the presence or absence of LPS as a costimulant to mimic an infectious environment. ELISA and zymography allowed us to evidence, in vitro, a specific increase in IL-8 and GRO-α secretion but not MIP-1β, TNF-α, or MMP-9, by PMNs. To assess in vivo relevance of these findings, we used a mouse air pouch model. Thanks to flow cytometry analysis, we highlighted an increased PMN recruitment with the copper(II) ions-doped samples compared to undoped samples. The immunomodulatory effect of copper(II) ions-doped BCP powders and the consequent induced moderate level of inflammation may promote bacterial clearance by PMNs in addition to the antimicrobial potential of the material. Copper(II) doping provides new insights into calcium phosphate (CaP)-based biomaterials for prosthesis coating or bone reconstruction by effectively modulating the inflammatory environment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | emse-04237635; https://hal-emse.ccsd.cnrs.fr/emse-04237635Test; https://hal-emse.ccsd.cnrs.fr/emse-04237635/documentTest; https://hal-emse.ccsd.cnrs.fr/emse-04237635/file/LT_OV%20Materials%20Today%20Bio%202023.pdfTest |
| DOI: | 10.1016/j.mtbio.2023.100814 |
| الإتاحة: | https://doi.org/10.1016/j.mtbio.2023.100814Test https://hal-emse.ccsd.cnrs.fr/emse-04237635Test https://hal-emse.ccsd.cnrs.fr/emse-04237635/documentTest https://hal-emse.ccsd.cnrs.fr/emse-04237635/file/LT_OV%20Materials%20Today%20Bio%202023.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A3F96E6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.mtbio.2023.100814 |
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