دورية أكاديمية
Liver and serum lipids in Wistar rats fed a novel structured lipid containing conjugated linoleic acid and conjugated linolenic acid ; Lípidos hepáticos y séricos en ratas Wistar alimentadas con nuevos lípidos estructurados que contienen ácido linoleico conjugado y ácido linolénico conjugado
| العنوان: | Liver and serum lipids in Wistar rats fed a novel structured lipid containing conjugated linoleic acid and conjugated linolenic acid ; Lípidos hepáticos y séricos en ratas Wistar alimentadas con nuevos lípidos estructurados que contienen ácido linoleico conjugado y ácido linolénico conjugado |
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| المؤلفون: | Shagholian, M., Goli, S. A.H., Shirvani, A., Agha-Ghazvini, M. R., Asgary, S. |
| المصدر: | Grasas y Aceites; Vol. 70 No. 2 (2019); e307 ; Grasas y Aceites; Vol. 70 Núm. 2 (2019); e307 ; 1988-4214 ; 0017-3495 ; 10.3989/gya.2019.v70.i2 |
| بيانات النشر: | Consejo Superior de Investigaciones Científicas |
| سنة النشر: | 2019 |
| المجموعة: | Grasas y Aceites (E-Journal) |
| مصطلحات موضوعية: | CLA oil, Fatty acids, HDL-C, LDL-C, Pomegranate seed oil, Aceite de CLA, Aceite de semilla de granada, Ácidos grasos |
| الوصف: | Conjugated linoleic acid (CLA) and conjugated linolenic acid (CLnA) have been known to have several health-promoting effects. The aim of this study was to introduce a novel structured lipid (SL) including both CLA and CLnA (cis9, trans11, cis13-18:3, punicic acid) into one triacylglycerol (TAG) molecule through enzymatic interesterification and investigate its effect on body weight, liver and serum lipids in Wistar rats. CLA oil, pomegranate seed oil (as a rich source of CLnA) and soybean oil (as a negative control) were applied as other experimental oils. The rats were fed the oils at 1500 mg/kg body weight per day via oral gavage for 45 days. Gas chromatography analysis showed that SL included CLnA and CLA in roughly equal concentrations. The in vivo study revealed that SL had the greatest effect on the reduction in liver lipid weight (4.65 g/100g of liver) and liver TAG (13.28 mg/g) compared to soybean oil (8.7 g/100g and 18.8 mg/g, respectively). High density lipoprotein cholesterol (HDL-C) in the serum of rats which were fed CLA oil significantly (p < 0.05) increased (from 0.95 to 1.14 mmol/l). Pomegranate seed oil reduced low density lipoprotein cholesterol (LDL-C) and total cholesterol (about 40% and 24% reduction, respectively). A remarkable TAG reduction (p < 0.05) was observed in all treated rats. ; Se sabe que el ácido linoleico conjugado (CLA) y el ácido linolénico conjugado (CLnA) tienen varios efectos positivos para la salud. El objetivo de este estudio fue producir un nuevo lípido estructurado (SL) que incluye tanto CLA como CLnA (cis9, trans11, cis13-18:3, ácido púnico) en una molécula de triacilglicerol (TAG) a través de la interesterificación enzimática e investigar su efecto en el cuerpo, peso, lípidos hepáticos y séricos en ratas Wistar. El aceite de CLA, el aceite de semilla de granada (como una fuente rica de CLnA) y el aceite de soja (como control negativo) se aplicaron como otros aceites experimentales. Las ratas fueron alimentadas con los aceites a razón de 1500 mg/kg de peso ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html; application/pdf; application/xml |
| اللغة: | English |
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| DOI: | 10.3989/gya.0582181 |
| الإتاحة: | https://doi.org/10.3989/gya.0582181Test https://doi.org/10.3989/gya.2019.v70.i2Test https://doi.org/10.1007/s11746-007-1158-xTest https://doi.org/10.1007/s11746-012-2096-9Test https://doi.org/10.1016/j.jfca.2004.09.002Test https://doi.org/10.1002/ejlt.200600025Test https://doi.org/10.1007/s11745-011-3585-6Test https://doi.org/10.1533/9781855736917.2.263Test https://doi.org/10.1002/ejlt.200700267Test https://doi.org/10.1016/j.cyto.2013.12.017Test |
| حقوق: | Copyright (c) 2019 Consejo Superior de Investigaciones Científicas (CSIC) ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.85C44D4B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3989/gya.0582181 |
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