دورية أكاديمية
Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
| العنوان: | Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion |
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| المؤلفون: | Morita, Rimpei, Schmitt, Nathalie, Bentebibel, Salah-Eddine, Ranganathan, Rajaram, Bourdery, Laure, Zurawski, Gerard, Foucat, Emile, Dullaers, Melissa, Oh, SangKon, Sabzghabaei, Nathalie, Lavecchio, Elizabeth M, Punaro, Marilynn, Pascual-Madorran, Virginia, Banchereau, Jacques, Ueno, Hideki |
| المصدر: | IMMUNITY ; ISSN: 1074-7613 |
| سنة النشر: | 2011 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Biology and Life Sciences, CHEMOKINE RECEPTOR EXPRESSION, RESPONSES, SYSTEMIC-LUPUS-ERYTHEMATOSUS, HELPER MEMORY CELLS, HUMAN TH17 CELLS, B-CELLS, GENE-EXPRESSION, DENDRITIC CELLS, IL-21, CUTTING EDGE |
| الوصف: | Although a fraction of human blood memory CD4(+) T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established. Here we show that human blood CXCR5(+)CD4(+) T cells share functional properties with Tfh cells and appear to represent their circulating memory compartment. Blood CXCR5(+)CD4(+) T cells comprised three subsets: T helper 1 (Th1), Th2, and Th17 cells. Th2 and Th17 cells within CXCR5(+), but not within CXCR5(-), compartment efficiently induced naive B cells to produce immunoglobulins via interleukin-21 (IL-21). In contrast, Th1 cells from both CXCR5(+) and CXCR5(-) compartments lacked the capacity to help B cells. Patients with juvenile dermatomyositis, a systemic autoimmune disease, displayed a profound skewing of blood CXCR5(+) Th cell subsets toward Th2 and Th17 cells. Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh cell subsets contributes to human autoimmunity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/1227911Test; http://hdl.handle.net/1854/LU-1227911Test; http://dx.doi.org/10.1016/j.immuni.2010.12.012Test; https://biblio.ugent.be/publication/1227911/file/1956412Test |
| DOI: | 10.1016/j.immuni.2010.12.012 |
| الإتاحة: | https://doi.org/10.1016/j.immuni.2010.12.012Test https://biblio.ugent.be/publication/1227911Test http://hdl.handle.net/1854/LU-1227911Test https://biblio.ugent.be/publication/1227911/file/1956412Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.3D03AB1E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.immuni.2010.12.012 |
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