دورية أكاديمية
Surgery in nasal polyp patients : outcome after a minimum observation of 10 years
| العنوان: | Surgery in nasal polyp patients : outcome after a minimum observation of 10 years |
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| المؤلفون: | Vlaminck, Stephan, Acke, Frederic, Prokopakis, Emmanuel, Speleman, Kato, Kawauchi, Hideyuki, van Cutsem, Jean-Christophe, Hellings, Peter, Jorissen, Mark, Seys, Sven, Bachert, Claus, Van Zele, Thibaut, Lambrecht, Bart, Gevaert, Philippe |
| المصدر: | AMERICAN JOURNAL OF RHINOLOGY & ALLERGY ; ISSN: 1945-8924 ; ISSN: 1945-8932 |
| سنة النشر: | 2021 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Immunology and Allergy, Otorhinolaryngology, General Medicine, asthma, adult onset asthma, chronic rhinosinusitis, CRSwNP, endoscopic sinus surgery, eosinophilic-rich mucus, follow-up, nasal polyps, outcome, SNOT-22, QUALITY-OF-LIFE, SINUS SURGERY, EOSINOPHILIA, RECURRENCE, MEDICINE, FUNGAL, IMPACT |
| الوصف: | Background Chronic rhinosinusitis with nasal polyps (CRSwNP) often requires surgery, but recurrence even after surgery is common. Recurrence rates largely vary in literature and asthma seems to be a comorbid factor. Objective In this study, we aim to estimate disease recurrence during a long-term follow-up, together with the investigation of possible predicting and/or influencing parameters. Methods Out of 196 patients operated for CRSwNP between 01/2000 and 01/2006, 133 patients had a follow-up of at least 10 years and could be included. The inflammatory profile at surgery was determined on nasal tissue and sinonasal secretions, and included analysis of eosinophils, eosinophilic-rich mucus (ERM) typically containing Charcot-Leyden crystals (CLC), and fungal hyphae (FH). During follow-up, recurrence, received treatments and comorbidities were collected. Results Out of the 133 included patients, local eosinophilia was present in 81% and ERM in 60%. Recurrence during follow-up was observed in 62%, and was associated with local eosinophilia and ERM (both p < 0.001). Asthma was present in 28% at inclusion, and 17% developed asthma after surgery during follow-up. The presence of asthma, at inclusion as well as developed during follow-up, was significantly associated with recurrence of CRSwNP (p = 0.001 for group comparison). Conclusion Recurrence after CRSwNP surgery is common when a long-term follow-up is taken into account. ERM detected in sinonasal secretions at surgery seems to be a predictive factor for recurrence and need for revision surgery. Asthma is a frequently found comorbid factor in CRSwNP, develops even at higher age despite surgical treatment for CRSwNP, and is also associated with a higher recurrence rate. Sustained medical care after surgery is mandatory. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/8696606Test; http://hdl.handle.net/1854/LU-8696606Test; http://dx.doi.org/10.1177/1945892420961964Test; https://biblio.ugent.be/publication/8696606/file/8696610Test |
| DOI: | 10.1177/1945892420961964 |
| الإتاحة: | https://doi.org/10.1177/1945892420961964Test https://biblio.ugent.be/publication/8696606Test http://hdl.handle.net/1854/LU-8696606Test https://biblio.ugent.be/publication/8696606/file/8696610Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.70451970 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1945892420961964 |
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