دورية أكاديمية
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
| العنوان: | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages |
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| المؤلفون: | Yang, Yunlong, Andersson, Patrik, Hosaka, Kayoko, Zhang, Yin, Cao, Renhai, Iwamoto, Hideki, Yang, Xiaojuan, Nakamura, Masaki, Wang, Jian, Zhuang, Rujie, Morikawa, Hiromasa, Xue, Yuan, Braun, Harald, Beyaert, Rudi, Samani, Nilesh, Nakae, Susume, Hams, Emily, Dissing, Steen, Fallon, Padraic G, Langer, Robert, Cao, Yihai |
| المصدر: | NATURE COMMUNICATIONS ; ISSN: 2041-1723 |
| سنة النشر: | 2016 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, GROWTH-FACTOR RECEPTOR, LIGAND-INDEPENDENT ACTIVATION, IN-VIVO, ST2 RECEPTOR, P38 MAPK, CD8(+) T, ANGIOGENESIS, CANCER, ZEBRAFISH, INFLAMMATION |
| الوصف: | Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain-and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/7236095Test; http://hdl.handle.net/1854/LU-7236095Test; http://dx.doi.org/10.1038/ncomms11385Test; https://biblio.ugent.be/publication/7236095/file/7236283Test |
| DOI: | 10.1038/ncomms11385 |
| الإتاحة: | https://doi.org/10.1038/ncomms11385Test https://biblio.ugent.be/publication/7236095Test http://hdl.handle.net/1854/LU-7236095Test https://biblio.ugent.be/publication/7236095/file/7236283Test |
| حقوق: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1B6AA56F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ncomms11385 |
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