دورية أكاديمية
Primary and metastatic peritoneal surface malignancies
| العنوان: | Primary and metastatic peritoneal surface malignancies |
|---|---|
| المؤلفون: | Cortés-Guiral, Delia, Hübner, Martin, Alyami, Mohammad, Bhatt, Aditi, Ceelen, Wim, Glehen, Olivier, Lordick, Florian, Ramsay, Robert, Sgarbura, Olivia, Van Der Speeten, Kurt, Turaga, Kiran K., Chand, Manish |
| المصدر: | NATURE REVIEWS DISEASE PRIMERS ; ISSN: 2056-676X |
| سنة النشر: | 2021 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, General Medicine, HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY, QUALITY-OF-LIFE, CYTOREDUCTIVE SURGERY CRS, ADVANCED OVARIAN-CANCER, ERAS(R) SOCIETY RECOMMENDATIONS, ENDOTHELIAL GROWTH-FACTOR, CELL-ADHESION MOLECULES, HIPEC ENHANCED RECOVERY, HUMAN MESOTHELIAL CELLS, FOLATE RECEPTOR-ALPHA |
| الوصف: | Peritoneal surface malignancies comprise a heterogeneous group of primary tumours, including peritoneal mesothelioma, and peritoneal metastases of other tumours, including ovarian, gastric, colorectal, appendicular or pancreatic cancers. The pathophysiology of peritoneal malignancy is complex and not fully understood. The two main hypotheses are the transformation of mesothelial cells (peritoneal primary tumour) and shedding of cells from a primary tumour with implantation of cells in the peritoneal cavity (peritoneal metastasis). Diagnosis is challenging and often requires modern imaging and interventional techniques, including surgical exploration. In the past decade, new treatments and multimodal strategies helped to improve patient survival and quality of life and the premise that peritoneal malignancies are fatal diseases has been dismissed as management strategies, including complete cytoreductive surgery embedded in perioperative systemic chemotherapy, can provide cure in selected patients. Furthermore, intraperitoneal chemotherapy has become an important part of combination treatments. Improving locoregional treatment delivery to enhance penetration to tumour nodules and reduce systemic uptake is one of the most active research areas. The current main challenges involve not only offering the best treatment option and developing intraperitoneal therapies that are equivalent to current systemic therapies but also defining the optimal treatment sequence according to primary tumour, disease extent and patient preferences. New imaging modalities, less invasive surgery, nanomedicines and targeted therapies are the basis for a new era of intraperitoneal therapy and are beginning to show encouraging outcomes. Peritoneal surface malignancies have heterogeneous origins, including primary peritoneal tumours and metastases of other cancers, for example, digestive tract, reproductive tract, lung, breast and kidney tumours. This Primer reviews the epidemiology, mechanisms and diagnosis of these diseases, and discusses ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/8731330Test; http://hdl.handle.net/1854/LU-8731330Test; http://dx.doi.org/10.1038/s41572-021-00326-6Test; https://biblio.ugent.be/publication/8731330/file/8731332Test |
| DOI: | 10.1038/s41572-021-00326-6 |
| الإتاحة: | https://doi.org/10.1038/s41572-021-00326-6Test https://biblio.ugent.be/publication/8731330Test http://hdl.handle.net/1854/LU-8731330Test https://biblio.ugent.be/publication/8731330/file/8731332Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.A8FBDED0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41572-021-00326-6 |
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