التفاصيل البيبلوغرافية
| العنوان: |
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| المؤلفون: |
Wyss, Annah B, Sofer, Tamar, Lee, Mi Kyeong, Terzikhan, Natalie, Nguyen, Jennifer N, Lahousse, Lies, Latourelle, Jeanne C, Smith, Albert Vernon, Bartz, Traci M, Feitosa, Mary F, Gao, Wei, Ahluwalia, Tarunveer S, Tang, Wenbo, Oldmeadow, Christopher, Duan, Qing, de Jong, Kim, Wojczynski, Mary K, Wang, Xin-Qun, Noordam, Raymond, Hartwig, Fernando Pires, Jackson, Victoria E, Wang, Tianyuan, Obeidat, Ma'en, Hobbs, Brian D, Huan, Tianxiao, Gui, Hongsheng, Parker, Margaret M, Hu, Donglei, Mogil, Lauren S, Kichaev, Gleb, Jin, Jianping, Graff, Mariaelisa, Harris, Tamara B, Kalhan, Ravi, Heckbert, Susan R, Paternoster, Lavinia, Burkart, Kristin M, Liu, Yongmei, Holliday, Elizabeth G, Wilson, James G, Vonk, Judith M, Sanders, Jason L, Barr, R Graham, de Mutsert, Renee, Baptista Menezes, Ana Maria, Adams, Hieab HH, van den Berge, Maarten, Joehanes, Roby, Levin, Albert M, Liberto, Jennifer, Launer, Lenore J, Morrison, Alanna C, Sitlani, Colleen M, Celedon, Juan C, Kritchevsky, Stephen B, Scott, Rodney J, Christensen, Kaare, Rotter, Jerome I, Bonten, Tobias N, Wehrmeister, Fernando Cesar, Bosse, Yohan, Xiao, Shujie, Oh, Sam, Franceschini, Nora, Brody, Jennifer A, Kaplan, Robert C, Lohman, Kurt, McEvoy, Mark, Province, Michael A, Rosendaal, Frits R, Taylor, Kent D, Nickle, David C, Williams, L Keoki, Burchard, Esteban G, Wheeler, Heather E, Sin, Don D, Gudnason, Vilmundur, North, Kari E, Fornage, Myriam, Psaty, Bruce M, Myers, Richard H, O'Connor, George, Hansen, Torben, Laurie, Cathy C, Cassano, Patricia A, Sung, Joohon, Kim, Woo Jin, Attia, John R, Lange, Leslie, Boezen, H Marike, Thyagarajan, Bharat, Rich, Stephen S, Mook-Kanamori, Dennis O, Horta, Bernardo Lessa, Uitterlinden, Andre G, Im, Hae Kyung, Cho, Michael H, Brusselle, Guy, Gharib, Sina A, Dupuis, Josee, Manichaikul, Ani, London, Stephanie J |
| المصدر: |
NATURE COMMUNICATIONS ; ISSN: 2041-1723 |
| سنة النشر: |
2018 |
| المجموعة: |
Ghent University Academic Bibliography |
| مصطلحات موضوعية: |
Medicine and Health Sciences, Biology and Life Sciences, GENOME-WIDE ASSOCIATION, AIR-FLOW OBSTRUCTION, LUNG-FUNCTION, SEGREGATION ANALYSIS, SMOKING-BEHAVIOR, SMOOTH-MUSCLE, LARGE-SCALE, FOLLOW-UP, DISEASE, VARIANTS |
| الوصف: |
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genomewide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic metaanalyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://biblio.ugent.be/publication/8572850Test; http://hdl.handle.net/1854/LU-8572850Test; http://dx.doi.org/10.1038/s41467-018-05369-0Test; https://biblio.ugent.be/publication/8572850/file/8572852Test |
| DOI: |
10.1038/s41467-018-05369-0 |
| الإتاحة: |
https://doi.org/10.1038/s41467-018-05369-0Test
https://biblio.ugent.be/publication/8572850Test
http://hdl.handle.net/1854/LU-8572850Test
https://biblio.ugent.be/publication/8572850/file/8572852Test |
| حقوق: |
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.58093E92 |
| قاعدة البيانات: |
BASE |
