المؤلفون: COVIDSurg Collaborative, missing, Dajti, I, Valenzuela, J I, Boccalatte, L A, Gemelli, N A, Smith, D E, Dudi-Venkata, N N, Kroon, H M, Sammour, T, Roberts, M, Mitchell, D, Lah, K, Pearce, A, Morton, A, Dawson, A C, Drane, A, Sharpin, C, Nataraja, R M, Pacilli, M, Cox, D R A, Muralidharan, V, Riddiough, G E, Clarke, E M, Jamel, W, Qin, K R, Pockney, P, Cope, D, Egoroff, N, Lott, N, Putnis, S, De Robles, S, Ang, Z, Mitteregger, M, Uranitsch, S, Stiegler, M, Seitinger, G, Aigner, F, Lumenta, D B, Nischwitz, P S, Richtig, E, Pau, M, Srekl-Filzmaier, P, Eibinger, N, Michelitsch, B, Fediuk, M, Papinutti, A, Seidel, G, Kahn, J, Cohnert, T U, Messner, D, Öfner, F, Presl, J, Varga, M, Weitzendorfer, M, Emmanuel, K, Binder, A D, Zimmermann, M, Holawe, S, Nkenke, E, Grimm, C, Kranawetter, M, Rahman Mitul, A, Islam, N, Karim, S, Komen, N, Ang, E, De Praetere, H, Tollens, T, Schols, G, Smets, C, Haenen, L, Quintens, J, Van Belle, K, van Ramshorst, Gabriëlle, Pattyn, P, Desender, L, Martens, T, Van de Putte, D, Lerut, P, Grimonprez, A, Janssen, M, De Smul, G, Wallaert, P, Van den Eynde, J, Oosterlinck, W, Van den Eynde, R, Sermon, A, Boeckxstaens, A, Cordonnier, A, De Coster, J, Jaekers, J, Politis, C, Miserez, M, Duchateau, N, De Gheldere, C, Flamey, N, Christiano, A, Guidi, B, Minussi, A L, Castro, S, Okoba, W, Maldonado, F H R, Oliveira, P, Baldasso, T, Santos, L, Gomes, G M A, Buarque, I L, Pol-Fachin, L, Bezerra, T S, Barros, A V, da Silva, A M R, Leite, A L S, Silvestre, D W A, Ferro, C C, Araujo, M S, Lopes, L M, Damasceno, P D, Araujo, D H S, Laporte, G, Salem, M C, Guimaraes-Filho, M A C, Nacif, L, Flumignan, R L G, Nakano, L C U, Kuramoto, D A B, Aidar, A L S, Pereda, M R, Correia, R M, Santos, B C, Carvalho, A A, Amorim, J E, Guedes Neto, H J, Areias, L L, Sousa, A F, Flumignan, C D Q, Lustre, W G, Moreno, D H, Barros, N, Baptista-Silva, J C C, Matos, L L, Kowaski, L P, Kulcsar, M A V, Nunes, K S, Teixeira, M F, Nunes, R L, Ijichi, T R, Kim, N J, Marreiro, A, Muller, B, Barakat Awada, J, Baiocchi, G, Kowalski, L P, Vartanian, J G, Makdissi, F B, Aguiar, S, Marques, N, Carvalho, G B, Marques, T M D M, Abdallah, E A, Zurstrassen, C E, Gross, J L, Zequi, S C, Gonçalves, B T, Santos, S S, Duprat, J P, Coimbra, F J F, Cicco, R, Takeda, F, Cecconello, I, Ribeiro, U, Gatti, A, Oliva, R, Nardi, C, Slavchev, M, Atanasov, B, Belev, N, Dell, A, Bigam, D, Dajani, K, Al Riyami, S, Martin, J, Cheng, D, Yang, H, Fayad, A, Carrier, F M, Amzallag, E, Desroches, J, Ruel, M, Caminsky, N G, Boutros, M, Moon, J, Wong, E G, Vanounou, T, Pelletier, J, Wong, S, Girsowicz, E, Bayne, J, Obrand, D, Gill, H, Steinmetz, O, MacKenzie, K, Lukaszewski, M, Jamjoum, G, Richebé, P, Verdonck, O, Discepola, S, Godin, N, Idrissi, M, Lecluyse, V, Côté, G, Demyttenaere, S, Garfinkle, R, Kouyoumdjian, A, Dumitra, S, Khwaja, K, Luo, L, Berry, G, Liberman, A S, Schmid, S, Spicer, J, Al Farsi, M, Abou-Khalil, J, Couture, E, Mohammadi, S, Tremblay, H, Gagné, N, Bergeron, A, Turgeon, A F, Costerousse, O, Bellemare, D, Babin, C, Blier, C, Wood, M L, Persad, A, Groot, G, Pham, H, D'Aragon, F, Carbonneau, E, Bouchard, M, Masse, M, Pesant, F, Héroux, J, Karanicolas, P, Hallet, J, Nadler, A, Nathens, A, Ko, M, Brar, A, Mayson, K, Kidane, B, Srinathan, S, Escudero, M I, Reyes, J T, Modolo, M M, Ramirez Nieto, P, Sepulveda, R, Bolbarán, A, Molero, A, Ruiz, I, Reyes, G P, Salas, R, Suazo, C, Muñoz, R, Grasset, E, Inzunza, M, Besser, N, Irarrázaval, M J, Jarry, C, Bellolio, F, Romero Manqui, C A, Ruiz Esquide, M, Fuentes, T, Campos, J, Perez Rivera, C J, Cabrera, P A, Pinilla, R E, Guevara, O, Jimenez Ramirez, L J, Velasquez Cuasquen, B G, Herrera Mora, D R, Bonilla, A, Diaz, S, Manrique, E, Facundo, H, Velez Bernal, J L, ángel, J, García, M, Guzmán, L, Lehmann, C, Cervera, S, Trujillo Sanchez, L M, Guevara, R, Valbuena, D, Suarez, L, Jimenez, G, Velandia, A, Vargas, J, Espinosa, J, Rey, S, Mendoza Quevedo, J, Calvache, J A, Orozco-Chamorro, C M, Sánchez-Gómez, T A, Rojas-Tejada, D A, Mihanovic, J, Bakmaz, B, Rakvin, I, Sulen, N, Andabaka, T, Luksic, I, Mamic, M, Martinek, L, Skrovina, M, Žatecký, J, Peteja, M, Kristensen, H Ø, Mekhael, M, Christensen, P, Westh, L, Smith, H, Haugstvedt, A F, JÖnsson, M L, Crespo, A, Batista, S, Rodriguez-Abreu, J, Tactuk, N, Diaz-Delgado, P J, Rivas, R, Sarmiento-Bobadilla, J A, Ashoush, F, Samir Abdelaal, A, Qatora, M S, Elsayed Hewalla, M E, Metwalli, M, Atta, R, Abdelmajeed, A, Abosamak, N E, Sabry, A, Shehata, S, Sallam, I, Amira, G, Sherief, M, Sherif, A, Salem, H, Hamdy, R, Aboulkassem, H, Ghaly, G, Sherif, G, Morsi, A, Abdelrahman, A, Omnia, A, Tawheed, A, El Kassas, M, Omar, W, Abdelsamed, A, Seleim, A, Azzam, A Y, ElFiky, M, Nabil, A, Ibraheem, M, ElDeeb, M, Fawzy, M, Hamed, H, Emile, S, Elfallal, A, Elfeki, H, Shalaby, M, Sakr, A, Alrahawy, M, Atif, H, Soltan, H, Sayed, A K, Salah, A, Atiya, A, Wassim, K, Esmail, E, Khalaf, M, Eldaly, A, Ghoneim, A, Hawila, A, Badr, H, Elhalaby, I, Abdel-bari, M, Elbahnasawy, M, Hamada, M K, Morsy, M S, Hammad, M, Essa, M, Fayed, M T, Elzoghby, M, Rady, M, Hamad, O, Salman, S, Sarsik, S, Abd-elsalam, S, Gamal Badr, S, El-Masry, Y, Moahmmed, M M H, Hailu, S, Wolde, A, Mengesha, M, Nida, S, Workneh, M, Ahmed, M Y, Fisseha, T, Kassa, D, Zeleke, H, Admasu, A, Laeke, T, Tirsit, A, Gessesse, M, Addissie, A, Bekele, D, Kauppila, J H, Sarjanoja, E, Testelin, S, Dakpé, S, Devauchelle, B, Bettoni, J, Lavagen, N, Schmitt, F, Lemée, J M, Boucher, S, Breheret, R, Kün-Darbois, J D, Kahn, A, Gueutier, A, Bigot, P, Borraccino, B, Lakkis, Z, Doussot, A, Heyd, B, Manfredelli, S, Mathieu, P, Paquette, B, Turco, C, Barrabe, A, Louvrier, A, Moszkowicz, D, Giovinazzo, D, Bretagnol, F, Police, A, Charre, L, Volpin, E, Braham, H, El Arbi, N, Villefranque, V, Bendjemar, L, Girard, E, Abba, J, Trilling, B, Chebaro, A, Lecolle, K, Truant, S, El Amrani, M, Zerbib, P, Pruvot, F R, Mathieu, D, Surmei, E, Mattei, L, Marin, H, Christou, N, Ballouhey, Q, Ferrero, P, Coste Mazeau, P, Tricard, J, Barrat, B, Taibi, A, Usseglio, J, Laloze, J, Salle, H, Fourcade, L, Duchalais, E, Regenet, N, Rigaud, J, Waast, D, Denis, W, Malard, O, Buffenoir, K, Espitalier, F, Ferron, C, Varenne, Y, Crenn, V, De Vergie, S, Cristini, J, Samarut, E, Tzedakis, S, Bouche, P A, Gaujoux, S, Kantor, E, Gossot, D, Seguin-Givelet, A, Fuks, D, Grigoroiu, M, Sanchez Salas, R, Cathelineau, X, Macek, P, Barbé, Y, Rozet, F, Barret, E, Mombet, A, Cathala, N, Brian, E, Zadegan, F, Conso, C, Blanc, T, Broch, A, Sarnacki, S, Ali, L, Bonnard, A, Peycelon, M, Hervieux, E, Clermidi, P, Maisonneuve, E, Aubry, E, Thomin, A, Langlais, T, Passot, G, Glehen, O, Cotte, E, Lifante, J C, De Simone, B, Chouillard, E, Arnaud, A P, Violas, P, Bergeat, D, Merdrignac, A, Scalabre, A, Perotto, L O, Le Roy, B, Haddad, E, Vermersch, S, Ezanno, A C, Barbier, O, Vigouroux, F, Malgras, B, Aime, A, Seeliger, B, Mutter, D, Philouze, G, Pessaux, P, Germain, A, Chanty, H, Ayav, A, Kassir, R, Von Theobald, P, Sauvat, F, O'Connor, J, Mayombo Idiata, M, O'Connor, Z, Tchoba, S, Modabber, A, Winnand, P, HÖlzle, F, Sommer, B, Shiban, E, Wolf, S, Anthuber, M, Sommer, F, Kaemmerer, D, Schreiber, T, Kamphues, C, Lauscher, J C, Schineis, C, Loch, F N, Beyer, K, Nasser, S, Sehouli, J, HÖhn, P, Braumann, C, Reinkemeier, F, Uhl, W, Weitz, J, Bork, U, Welsch, T, Praetorius, C, Korn, S, Distler, M, Fluegen, G, Knoefel, W T, Vay, C, Golcher, H, Grützmann, R, Binder, J, Meister, P, Gallinat, A, Paul, A, Schnitzbauer, A A, Thoenissen, P, El Youzouri, H, Schreckenbach, T, Nguyen, T A, Eberbach, H, Bayer, J, Erdle, B, Sandkamp, R, Nitschke, C, Izbicki, J, Uzunoglu, F G, Koenig, D, Gosau, M, BÖttcher, A, Heuer, A, Klatte, T O, Priemel, M, Betz, C S, Burg, S, MÖckelmann, N, Busch, C J, Bewarder, J, Zeller, N, Smeets, R, Thole, S, Vollkommer, T, Speth, U, Stangenberg, M, Hakami, I, Boeker, C, Mall, J, Schardey, H M, von Ahnen, T, von Ahnen, M, Brunner, U, Tapking, C, Kneser, U, Hirche, C, Jung, M, Kowalewski, K F, 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المصدر: BRITISH JOURNAL OF SURGERY ; ISSN: 0007-1323 ; ISSN: 1365-2168

مصطلحات موضوعية: Medicine and Health Sciences, Surgery

الوصف: To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in surgical patients with SARS-CoV-2. We found that patient rather than operation factors were the best predictors and used these to create the COVIDsurg Mortality Score (https://covidsurgrisk.appTest). Our data demonstrates that it is safe to restart a wide range of surgical services for selected patients.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8731685Test; http://hdl.handle.net/1854/LU-8731685Test; http://dx.doi.org/10.1093/bjs/znab183Test; https://biblio.ugent.be/publication/8731685/file/01H16QWAABWGMCB2T9JEMEZVMZTest

الإتاحة: https://doi.org/10.1093/bjs/znab183Test
https://biblio.ugent.be/publication/8731685Test
http://hdl.handle.net/1854/LU-8731685Test
https://biblio.ugent.be/publication/8731685/file/01H16QWAABWGMCB2T9JEMEZVMZTest

المؤلفون: Chin, L, Meyerson, M, Aldape, K, Bigner, D, Mikkelsen, T, VandenBerg, S, Kahn, A, Penny, R, Ferguson, ML, Gerhard, DS, Getz, G, Brennan, C, Taylor, BS, Winckler, W, Park, P, Ladanyi, M, Hoadley, KA, Verhaak, RGW, Hayes, DN, Spellman, Paul T, Absher, D, Weir, BA, Ding, L, Wheeler, D, Lawrence, MS, Cibulskis, K, Mardis, E, Zhang, JingHui, Wilson, RK, Donehower, L, Wheeler, DA, Purdom, E, Wallis, J, Laird, PW, Herman, JG, Schuebel, KE, Weisenberger, DJ, Baylin, SB, Schultz, N, Yao, J, Wiedemeyer, R, Weinstein, J, Sander, C, Gibbs, RA, Gray, J, Kucherlapati, R, Lander, ES, Myers, RM, Perou, CM, McLendon, Roger, Friedman, Allan, Van Meir, Erwin G, Brat, Daniel J, Mastrogianakis, Gena Marie, Olson, Jeffrey J, Lehman, Norman, Yung, WK Alfred, Bogler, Oliver, Berger, Mitchel, Prados, Michael, Muzny, Donna, Morgan, Margaret, Scherer, Steve, Sabo, Aniko, Nazareth, Lynn, Lewis, Lora, Hall, Otis, Zhu, YiMing, Ren, YanRu, Alvi, Omar, Yao, JiQiang, Hawes, Alicia, Jhangiani, Shalini, Fowler, Gerald, San Lucas, Anthony, Kovar, Christie, Cree, Andrew, Dinh, Huyen, Santibanez, Jireh, Joshi, Vandita, Gonzalez-Garay, Manuel L, Miller, Christopher A, Milosavljevic, Aleksandar, Sougnez, Carrie, Fennell, Tim, Mahan, Scott, Wilkinson, Jane, Ziaugra, Liuda, Onofrio, Robert, Bloom, Toby, Nicol, Rob, Ardlie, Kristin, Baldwin, Jennifer, Gabriel, Stacey, Fulton, Robert S, McLellan, Michael D, Larson, David E, Shi, XiaoQi, Abbott, Rachel, Fulton, Lucinda, Chen, Ken, Koboldt, Daniel C, Wendl, Michael C, Meyer, Rick, Tang, YuZhu, Lin, Ling, Osborne, John R, Dunford-Shore, Brian H, Miner, Tracie L, Delehaunty, Kim, Markovic, Chris, Swift, Gary, Courtney, William, Pohl, Craig, Abbott, Scott, Hawkins, Amy, Leong, Shin, Haipek, Carrie, Schmidt, Heather, Wiechert, Maddy, Vickery, Tammi, Scott, Sacha, Dooling, David J, Chinwalla, Asif, Weinstock, George M, O'Kelly, Michael, Robinson, Jim, Alexe, Gabriele, Beroukhim, Rameen, Carter, Scott, Chiang, Derek, Gould, Josh, Gupta, Supriya, Korn, Josh, Mermel, Craig, Mesirov, Jill, Monti, Stefano, Nguyen, Huy, Parkin, Melissa, Reich, Michael, Stransky, Nicolas, Garraway, Levi, Golub, Todd, Protopopov, Alexei, Perna, Ilana, Aronson, Sandy, Sathiamoorthy, Narayan, Ren, Georgia, Kim, Hyunsoo, Kong, Sek Won, Xiao, YongHong, Kohane, Isaac S, Seidman, Jon, Cope, Leslie, Pan, Fei, Van Den Berg, David, Van Neste, Leander, Yi, Joo Mi, Li, Jun Z, Southwick, Audrey, Brady, Shannon, Aggarwal, Amita, Chung, Tisha, Sherlock, Gavin, Brooks, James D, Jakkula, Lakshmi R, Lapuk, Anna V, Marr, Henry, Dorton, Shannon, Choi, Yoon Gi, Han, Ju, Ray, Amrita, Wang, Victoria, Durinck, Steffen, Robinson, Mark, Wang, Nicholas J, Vranizan, Karen, Peng, Vivian, Van Name, Eric, Fontenay, Gerald V, Ngai, John, Conboy, John G, Parvin, Bahram, Feiler, Heidi S, Speed, Terence P, Socci, Nicholas D, Olshen, Adam, Lash, Alex, Reva, Boris, Antipin, Yevgeniy, Stukalov, Alexey, Gross, Benjamin, Cerami, Ethan, Wang, Wei Qing, Qin, Li-Xuan, Seshan, Venkatraman E, Villafania, Liliana, Cavatore, Magali, Borsu, Laetitia, Viale, Agnes, Gerald, William, Topal, Michael D, Qi, Yuan, Balu, Sai, Shi, Yan, Wu, George, Bittner, Michael, Shelton, Troy, Lenkiewicz, Elizabeth, Morris, Scott, Beasley, Debbie, Sanders, Sheri, Sfeir, Robert, Chen, Jessica, Nassau, David, Feng, Larry, Hickey, Erin, Schaefer, Carl, Madhavan, Subha, Buetow, Ken, Barker, Anna, Vockley, Joseph, Compton, Carolyn, Vaught, Jim, Fielding, Peter, Collins, Francis, Good, Peter, Guyer, Mark, Ozenberger, Brad, Peterson, Jane, Thomson, Elizabeth

المصدر: NATURE ; ISSN: 0028-0836

مصطلحات موضوعية: Biology and Life Sciences, HIGH-FREQUENCY, PIK3CA GENE, ALKYLATING-AGENTS, MALIGNANT GLIOMAS, SOMATIC MUTATIONS, NEUROFIBROMATOSIS TYPE-1, MISMATCH REPAIR, NF1 GENE, CELL-LINES, TUMORS

الوصف: Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/1053670Test; http://hdl.handle.net/1854/LU-1053670Test; http://dx.doi.org/10.1038/nature07385Test; https://biblio.ugent.be/publication/1053670/file/1053904Test

الإتاحة: https://doi.org/10.1038/nature07385Test
https://biblio.ugent.be/publication/1053670Test
http://hdl.handle.net/1854/LU-1053670Test
https://biblio.ugent.be/publication/1053670/file/1053904Test