التفاصيل البيبلوغرافية
| العنوان: |
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations |
| المؤلفون: |
Sakornsakolpat, Phuwanat, Prokopenko, Dmitry, Lamontagne, Maxime, Reeve, Nicola F, Guyatt, Anna L, Jackson, Victoria E, Shrine, Nick, Qiao, Dandi, Bartz, Traci M, Kim, Deog Kyeom, Lee, Mi Kyeong, Latourelle, Jeanne C, Li, Xingnan, Morrow, Jarrett D, Obeidat, Ma'en, Wyss, Annah B, Bakke, Per, Barr, R Graham, Beaty, Terri H, Belinsky, Steven A, Brusselle, Guy, Crapo, James D, de Jong, Kim, DeMeo, Dawn L, Fingerlin, Tasha E, Gharib, Sina A, Gulsvik, Amund, Hall, Ian P, Hokanson, John E, Kim, Woo Jin, Lomas, David A, London, Stephanie J, Meyers, Deborah A, O'Connor, George T, Rennard, Stephen I, Schwartz, David A, Sliwinski, Pawel, Sparrow, David, Strachan, David P, Tal-Singer, Ruth, Tesfaigzi, Yohannes, Vestbo, Jorgen, Vonk, Judith M, Yim, Jae-Joon, Zhou, Xiaobo, Bosse, Yohan, Manichaikul, Ani, Lahousse, Lies, Silverman, Edwin K, Boezen, H Marike, Wain, Louise V, Tobin, Martin D, Hobbs, Brian D, Cho, Michael H, Batini, Chiara, Zhao, Jing Hua, Wielscher, Matthias, Weiss, Stefan, Kentistou, Katherine A, Cook, James P, Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E, Marten, Jonathan, Enroth, Stefan, Kerr, Shona M, Surakka, Ida, Vitart, Veronique, Lehtimaki, Terho, Ewert, Ralf, Gieger, Christian, Homuth, Georg, Joshi, Peter K, Langenberg, Claudia, Lind, Lars, Luan, Jianan, Mahajan, Anubha, Murray, Alison, Porteous, David J, Rawal, Rajesh, Smith, Blair H, Timmers, Paul RHJ, Raitakari, Olli T, Kahonen, Mika, Polasek, Ozren, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J, Probst-Hensch, Nicole M, Schulz, Holger, James, Alan L, Wilson, James F, Stubbe, Beate, Zeggini, Eleftheria, Jarvelin, Marjo-Riitta, Wareham, Nick, Hayward, Caroline, Morris, Andrew P, Agusti, Alvar, Anderson, Wayne, Bakerly, Nawar, Bals, Robert, Barnes, Kathleen C, Bleecker, Eugene R, Bowler, Russell, Brightling, Christopher, de Bruijne, Marleen, Castaldi, Peterj, Celli, Bartolome, Coxson, Harvey O, Crystal, Ron, de Jong, Pim, Dirksen, Asger, Dy, Jennifer, Foreman, Marilyn, Garcia-Aymerich, Judith, Gevenois, Pierre, Ghosh, Soumitra, Gietema, Hester, Hansel, Nadia, Hersh, Craig P, Hoffman, Eric, Kalsheker, Noor, Kauczor, Hans-Ulrich, Laitinen, Tarja, Lambrechts, Diether, Litonjua, Augusto A, Loth, Daan W, Lutz, Sharon M, Lynch, David, MacNee, William, McDonald, Merry-Lynn, Newell, John D, Nordestgaard, Borge G, Oh, Yeon-Mok, Pare, Peter D, Pistolesi, Massimo, Postma, Dirkje S, Puhan, Milo, Regan, Elizabeth, Rich, Stephen S, Seo, Joon Beom, Short, Andrea, Stoel, Berend, Sverzellati, Nicola, ter Riet, Gerben, Van Beek, Edwin JR, Van Ginneken, Bram, Vogelmeier, Claus F, Wanner, Adam, Washko, George, Wauters, Els, Wouters, Emiel FM, Young, Robert P, Zeigler-Heitbrock, Loems |
| المصدر: |
NATURE GENETICS ; ISSN: 1061-4036 ; ISSN: 1546-1718 |
| سنة النشر: |
2019 |
| المجموعة: |
Ghent University Academic Bibliography |
| مصطلحات موضوعية: |
Medicine and Health Sciences, Biology and Life Sciences, GENOME-WIDE ASSOCIATION, ACIDIC-MAMMALIAN-CHITINASE, LD SCORE, REGRESSION, LUNG-FUNCTION, EXTRACELLULAR-MATRIX, PREDOMINANT EMPHYSEMA, CONNECTIVITY MAP, ATOPIC ASTHMA, RISK LOCI, GWAS |
| الوصف: |
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 x 10(-8); 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://biblio.ugent.be/publication/8610457Test; http://hdl.handle.net/1854/LU-8610457Test; http://dx.doi.org/10.1038/s41588-018-0342-2Test; https://biblio.ugent.be/publication/8610457/file/8645896Test |
| DOI: |
10.1038/s41588-018-0342-2 |
| الإتاحة: |
https://doi.org/10.1038/s41588-018-0342-2Test
https://biblio.ugent.be/publication/8610457Test
http://hdl.handle.net/1854/LU-8610457Test
https://biblio.ugent.be/publication/8610457/file/8645896Test |
| حقوق: |
No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsbas.6CAA1DD0 |
| قاعدة البيانات: |
BASE |
