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1دورية أكاديمية
المؤلفون: Antychin, T., Zarowski, J. A., Verplancke, V., Hendriks, J. M. H., Yogeswaran, S. K., Lauwers, P., Lamote, Kevin, Kwakkel-van Erp, J. M.
المصدر: INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE ; ISSN: 2008-6490 ; ISSN: 2008-6482
مصطلحات موضوعية: MTOR INHIBITORS, CYCLOSPORINE, TACROLIMUS, Calcineurin inhibitors, mTOR-inhibitor, Lung transplantation, Reversible neuropathy
الوصف: YYYYY Calcineurin inhibitors (CNIs) are regarded as a corner stone in immunosuppressive therapy after solid organ transplantation. However, neurotoxicity is a common side effect of CNIs, resulting in a wide range of neurological symptoms such as headache, tremor and seizures. In this case report, we describe a patient who developed severe motor and sensory neuron dysfunction related to CNIs after bilateral lung transplantation, which resolved after halting CNI and switching to a mammalian Target of Rapamycin-inhibitor.
وصف الملف: application/pdf
العلاقة: https://biblio.ugent.be/publication/01HVR3M2BTYM6R0QBSNH9AP9A5Test; http://hdl.handle.net/1854/LU-01HVR3M2BTYM6R0QBSNH9AP9A5Test; https://biblio.ugent.be/publication/01HVR3M2BTYM6R0QBSNH9AP9A5/file/01HVR6AQABTJ8TD3Z6K5NDEKWQTest
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2دورية أكاديمية
المؤلفون: Pipeleers, Lissa, Abramowicz, Daniel, Broeders, Nilufer, Lemoine, Alain, Peeters, Patrick, Van Laecke, Steven, Weekers, Laurent E., Sennesael, Jacques, Wissing, Karl M., Geers, Caroline, Bosmans, Jean-Louis
المصدر: TRANSPLANT INTERNATIONAL ; ISSN: 0934-0874 ; ISSN: 1432-2277
مصطلحات موضوعية: Medicine and Health Sciences, calcineurin inhibitor, cyclosporine, everolimus, immunosuppression, kidney transplantation, mTOR inhibitors, CHRONIC ALLOGRAFT NEPHROPATHY, RENAL-CELL CARCINOMA, EARLY CONVERSION, DIABETES-MELLITUS, MYCOPHENOLATE-MOFETIL, ACUTE REJECTION, RAPAMYCIN INHIBITORS, MAMMALIAN TARGET, CONTROLLED-TRIAL
الوصف: Withdrawal of either steroids or calcineurin inhibitors are two strategies to reduce treatment-related side effects and improve long-term outcomes of kidney transplantation. The CISTCERT study compared the efficacy and safety of these two strategies. In this multicenter, randomized controlled trial, 151 incident kidney transplant recipients received cyclosporine (CsA), mycophenolic acid (MPA), and steroids during three months, followed by either steroid withdrawal (CsA/MPA) or replacement of cyclosporine with everolimus (EVL) (EVL/MPA/steroids). 5-year patient survival (89% vs. 86%; P = NS) and death-censored graft survival (95% vs. 96%; P = NS) were comparable in the CsA/MPA and EVL/MPA/steroids arm, respectively. 51 CrEDTA clearance was comparable in the intention-to-treat analysis, but in the on-treatment population, the EVL/MPA/steroids arm exhibited a superior 51 CrEDTA clearance at 1 and 5 years after transplantation (61.6 vs. 52.4, P = 0.05 and 59.1 vs. 46.2ml/min/1.73 m2 , P = 0.042). Numerically more and more severe rejections were observed in the EVL/MPA/steroids arm, which also experienced a higher incidence of posttransplant diabetes (26% vs. 6%, P = 0.0016) and infections. No significant differences were observed in cardiovascular outcomes and malignancy. Both regimens provide an excellent long-term patient survival and graft survival. Regarding graft function, EVL/MPA/steroids is an attractive strategy for patients with good tolerability who remain free of rejection. (ClinicalTrials.gov number: NCT00903188; EudraCT Number 2007-005844-26).
وصف الملف: application/pdf
العلاقة: https://biblio.ugent.be/publication/8698633Test; http://hdl.handle.net/1854/LU-8698633Test; http://dx.doi.org/10.1111/tri.13798Test; https://biblio.ugent.be/publication/8698633/file/8698637Test
الإتاحة: https://doi.org/10.1111/tri.13798Test
https://biblio.ugent.be/publication/8698633Test
http://hdl.handle.net/1854/LU-8698633Test
https://biblio.ugent.be/publication/8698633/file/8698637Test -
3دورية أكاديمية
المصدر: SYNTHESIS-STUTTGART ; ISSN: 0039-7881
مصطلحات موضوعية: Chemistry, ring closure, alkylation, heterocycles, rearrangement, hydrogenation, CANCER-THERAPY, MTOR INHIBITORS
الوصف: An efficient synthesis of furo[3,4-d]pyrimidine-2,4-diones has been accomplished via a straightforward three-step pathway. Curtius rearrangement of 4-(methoxycarbonyl)furan-3-carboxylic acid and subsequent reaction with a variety of amines resulted in the corresponding intermediate ureids, which could be ring closed to the bicyclic scaffold in good yields. Functionalization of N-1 afforded a small library of new heterocycles. (Partial) hydrogenation of the furo[3,4-d]pyrimidine- 2,4-diones led to the 5,7-dihydro- and tetrahydrofuro[3,4-d]pyrimidine- 2,4-diones.
وصف الملف: application/pdf
العلاقة: https://biblio.ugent.be/publication/5956099Test; http://hdl.handle.net/1854/LU-5956099Test; http://dx.doi.org/10.1055/s-0034-1380321Test; https://biblio.ugent.be/publication/5956099/file/5956106Test
الإتاحة: https://doi.org/10.1055/s-0034-1380321Test
https://biblio.ugent.be/publication/5956099Test
http://hdl.handle.net/1854/LU-5956099Test
https://biblio.ugent.be/publication/5956099/file/5956106Test
