دورية أكاديمية
Cataplexy and its mimics : clinical recognition and management
| العنوان: | Cataplexy and its mimics : clinical recognition and management |
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| المؤلفون: | Pillen, Sigrid, Pizza, Fabio, Dhondt, Karlien, Scammell, Thomas, Overeem, Sebastiaan |
| المصدر: | CURRENT TREATMENT OPTIONS IN NEUROLOGY ; ISSN: 1092-8480 ; ISSN: 1534-3138 |
| سنة النشر: | 2017 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Cataplexy, Narcolepsy, Pseudocataplexy, Drop attacks, Syncope, Sodium oxybate, EXCESSIVE DAYTIME SLEEPINESS, PRADER-WILLI-SYNDROME, COFFIN-LOWRY-SYNDROME, OREXIN KNOCKOUT MICE, LIMP MAN SYNDROME, LONG-QT SYNDROME, CHILDHOOD NARCOLEPSY, STATUS CATAPLECTICUS, INTRAVENOUS IMMUNOGLOBULINS |
| الوصف: | This review describes the diagnosis and management of cataplexy: attacks of bilateral loss of muscle tone, triggered by emotions and with preserved consciousness. Although cataplexy is rare, its recognition is important as in most cases, it leads to a diagnosis of narcolepsy, a disorder that still takes a median of 9 years to be diagnosed. The expression of cataplexy varies widely, from partial episodes affecting only the neck muscles to generalized attacks leading to falls. Moreover, childhood cataplexy differs from the presentation in adults, with a prominent facial involvement, already evident without clear emotional triggers ('cataplectic facies') and 'active' motor phenomena especially of the tongue and perioral muscles. Next to narcolepsy, cataplexy can sometimes be caused by other diseases, such as Niemann-Pick type C, Prader Willi Syndrome, or lesions in the hypothalamic or pontomedullary region. Cataplexy mimics include syncope, epilepsy, hyperekplexia, drop attacks and pseudocataplexy. They can be differentiated from cataplexy using thorough history taking, supplemented with (home) video recordings whenever possible. Childhood narcolepsy, with its profound facial hypotonia, can be confused with neuromuscular disorders, and the active motor phenomenona resemble those found in childhood movement disorders such as Sydenham's chorea. Currently, the diagnosis of cataplexy is made almost solely on clinical grounds, based on history taking and (home) videos. Cataplexy shows remarkable differences in childhood compared to adults, with profound facial hypotonia and complex active motor phenomena. Over time, these severe symptoms evolve to the milder adult phenotype, and this pattern is crucial to recognize when assessing the outcome of uncontrolled case series with potential treatments such as immunomodulation. Symptomatic treatment is possible with antidepressants and sodium oxybate. Importantly, management also needs to involve sleep hygiene advice, safety measures whenever applicable and guidance with regard ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/8563085Test; http://hdl.handle.net/1854/LU-8563085Test; http://dx.doi.org/10.1007/s11940-017-0459-0Test; https://biblio.ugent.be/publication/8563085/file/8612640Test |
| DOI: | 10.1007/s11940-017-0459-0 |
| الإتاحة: | https://doi.org/10.1007/s11940-017-0459-0Test https://biblio.ugent.be/publication/8563085Test http://hdl.handle.net/1854/LU-8563085Test https://biblio.ugent.be/publication/8563085/file/8612640Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.1602AB3D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11940-017-0459-0 |
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