تقرير
Effect of olmesartan on oxidative stress in hemodialysis patients.
| العنوان: | Effect of olmesartan on oxidative stress in hemodialysis patients. |
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| المؤلفون: | 門脇 大介, 安楽 誠, 田先 由佳, 北村 健一郎, 若松 志保, 冨田 公夫, Gebicki Janusz M, 丸山 徹, 小田切 優樹 |
| بيانات النشر: | 福山大学薬学部 |
| سنة النشر: | 2008 |
| المجموعة: | Fukuyama University Repository / 福山大学学術情報リポジトリ |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Angiotensin II Type 1 Receptor Blockers, Antioxidants, Blood Pressure, Female, Humans, Hypertension, Renal, Imidazoles, Kidney Failure, Chronic, Male, Middle Aged, Oxidative Stress, Peroxides, Placebos, Renal Dialysis, Serum Albumin, Tetrazoles, Uremia |
| الوصف: | The effect of olmesartan, an inverse angiotensin II type 1 receptor blocker (ARB), on oxidative stress in hemodialysis (HD) patients is not fully understood, and has not been widely investigated in vitro or in vivo. We determined the amount of oxidized albumin and albumin hydroperoxides formed during incubation in the absence and presence of olmesartan by high-performance liquid chromatography (HPLC) and by a ferrous oxidation xylenol assay in an in vitro study. Six hypertensive HD patients were treated with 40 mg of olmesartan once daily, and blood pressure monitoring (BPM) was performed after 0, 4, and 8 weeks of treatment. The ratio of oxidized to unoxidized albumin was also determined. The oxidized albumin ratios and levels of albumin hydroperoxides were significantly decreased in a concentration-dependent manner in the presence of olmesartan, compared with the absence of olmesartan (p<0.05) in in vitro studies. In HD patients, olmesartan also significantly reduced systolic and diastolic blood pressure after 4 weeks, with a further significant decrease after 8 weeks. The ratio of oxidized to unoxidized albumin was markedly decreased after 4 weeks and these lower levels were maintained at 8 weeks. Olmesartan effectively lowered the extent of oxidation of albumin in both in vitro and in vivo studies, and this effect might confer benefits beyond a reduction in blood pressure. ; The effect of olmesartan, an inverse angiotensin II type 1 receptor blocker (ARB), on oxidative stress in hemodialysis (HD) patients is not fully understood, and has not been widely investigated in vitro or in vivo. We determined the amount of oxidized albumin and albumin hydroperoxides formed during incubation in the absence and presence of olmesartan by high-performance liquid chromatography (HPLC) and by a ferrous oxidation xylenol assay in an in vitro study. Six hypertensive HD patients were treated with 40 mg of olmesartan once daily, and blood pressure monitoring (BPM) was performed after 0, 4, and 8 weeks of treatment. The ... |
| نوع الوثيقة: | report |
| اللغة: | English |
| تدمد: | 0288-724X |
| العلاقة: | https://fukuyama-u.repo.nii.ac.jp/?action=repository_uri&item_id=8544Test; http://id.nii.ac.jp/1064/00008500Test/; 福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University, (26), 61-61(2008-12-25); AN10064550; https://fukuyama-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=8544&item_no=1&attribute_id=22&file_no=1Test |
| الإتاحة: | https://fukuyama-u.repo.nii.ac.jp/?action=repository_uri&item_id=8544Test http://id.nii.ac.jp/1064/00008500Test/ https://fukuyama-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=8544&item_no=1&attribute_id=22&file_no=1Test |
| رقم الانضمام: | edsbas.2BE8A2DE |
| قاعدة البيانات: | BASE |
| تدمد: | 0288724X |
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