التفاصيل البيبلوغرافية
| العنوان: |
Bioactivity of Biosilica Obtained From North Atlantic Deep-Sea Sponges |
| المؤلفون: |
Dudik, Olesia, Amorim, Sara, Xavier, Joana R., Rapp, Hans Tore, Silva, Tiago H., Pires, Ricardo A., Reis, Rui L. |
| المساهمون: |
Horizon 2020 Framework Programme |
| المصدر: |
Frontiers in Marine Science ; volume 8 ; ISSN 2296-7745 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Ocean Engineering, Water Science and Technology, Aquatic Science, Global and Planetary Change, Oceanography |
| الوصف: |
Demosponges are a well-known source of a plethora of bioactive compounds. In particular, they are able to form a skeleton by direct deposition of silica in a process catalyzed by silicatein. Herein, we isolated biosilicas from five different Atlantic deep-sea sponges Geodia atlantica (GA), Geodia barretti (GB), Stelletta normani (SN), Axinella infundibuliformis (AI), and Phakellia ventilabrum (PV) to explore the bioactivity and osteogenic capacity of its silica-based materials. We chemically characterized the isolated biosilicas and evaluated them for their bioactivity to deposit Ca and P on their surface (by immersion in simulated body fluid, SBF). GB-, SN-, AI-, and PV-based biosilicas did not generate a stable calcium phosphate (CaP) layer over time in the presence of SBF, however, the GA-derived one was able to form a CaP surface layer (at a Ca/P ratio of ∼1.7, similar to the one observed for hydroxyapatite), that was stable during the 28 days of testing. In addition, no cytotoxicity toward L929 and SaOs2 cells was observed for the GA-based biosilica up to a concentration of 10 mg/mL. Overall, the GA-based biosilica presents the characteristics to be used in the development of biomaterials for bone tissue engineering (BTE). |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fmars.2021.637810 |
| DOI: |
10.3389/fmars.2021.637810/full |
| الإتاحة: |
https://doi.org/10.3389/fmars.2021.637810Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.E6B60A |
| قاعدة البيانات: |
BASE |
