التفاصيل البيبلوغرافية
| العنوان: |
Dual-energy computed tomography to detect early pulmonary vascular changes in children with sickle cell disease: a pilot study |
| المؤلفون: |
Joye, Raphael, Wacker, Julie, Nguyen, Duy-Anh, Hachulla, Anne-Lise, Maggio, Albane B. R., Cimasoni, Laurent, Lador, Frederic, Ansari, Marc, Beghetti, Maurice |
| المساهمون: |
University of Geneva |
| المصدر: |
Frontiers in Pediatrics ; volume 11 ; ISSN 2296-2360 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Pediatrics, Perinatology and Child Health |
| الوصف: |
Introduction Pulmonary hypertension (PH) is a rare but fatal complication of sickle cell disease (SCD) that is possibly reversible if treated early. Dual-energy computed tomography (DECT) is a valuable tool for diagnosing PH. We attempted to determine if DECT can detect early signs of PH in children with SCD. Methods This prospective observational pilot study was conducted at the Geneva University Hospitals and was approved by the local human ethics committee (CCER 2019-01975). A written informed consent was obtained from the patients and/or their legal guardian. Eight children (consisting of five girls and three boys) with homozygous SCD were included in the study. They underwent full cardiological workup using transthoracic echocardiography (TTE) and cardiopulmonary exercise test (CPET), as well as DECT. Results The median age of the children was 11 years old (range 8–12). All patients exhibited a normal biventricular systo-diastolic function using the TTE. The median tricuspid regurgitant jet velocity value was 2.24 m/s (range 1.96–2.98). Four children were found to have signs of vasculopathy detected on DECT. Of them, two had abnormal screening test results. They both had an increased VE/VCO 2 slope during CPET and an increased TVR of >2.5 m/s on TTE. Conclusion DECT is capable of identifying early signs of pulmonary vascular disease in children with SCD. Further studies are needed to understand the correlation between DECT abnormalities and hemodynamic pulmonary circulation better. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fped.2023.1221977 |
| DOI: |
10.3389/fped.2023.1221977/full |
| الإتاحة: |
https://doi.org/10.3389/fped.2023.1221977Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.89BAF171 |
| قاعدة البيانات: |
BASE |
