دورية أكاديمية
Factors associated with adverse COVID-19 outcomes in patients with psoriasis – insights from a global registry-based study
| العنوان: | Factors associated with adverse COVID-19 outcomes in patients with psoriasis – insights from a global registry-based study |
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| المؤلفون: | Mahil, Satveer K., Dand, Nick, Mason, Kayleigh J., Yiu, Zenas ZN., Tsakok, Teresa, Meynell, Freya, Coker, Bola, McAteer, Helen, Moorhead, Lucy, Mackenzie, Teena, Rossi, Maria Teresa, Rivera, Raquel, Mahe, Emmanuel, Carugno, Andrea, Magnano, Michela, Rech, Giulia, Balogh, Esther A., Feldman, Steven R., Cruz, Claudia De La, Choon, Siew Eng, Naldi, Luigi, Lambert, Jo, Spuls, Phyllis, Jullien, Denis, Bachelez, Hervé, McMahon, Devon E., Freeman, Esther E., Gisondi, Paolo, Puig, Luis, Warren, Richard B., Meglio, Paola Di, Langan, Sinéad M., Capon, Francesca, Griffiths, Christopher EM., FMedSci, MD, Barker, Jonathan N., Smith, Catherine H. |
| المصدر: | reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano |
| بيانات النشر: | Journal of Allergy and Clinical Immunology |
| سنة النشر: | 2020 |
| المجموعة: | Expeditio - Repositorio Institucional Universidad de Bogotá Jorge Tadeo Lozano (UTADEO) |
| مصطلحات موضوعية: | COVID-19, Hospitalization, Psoriasis, Risk factors, Biologics, Mmunosuppressants, Síndrome respiratorio agudo grave, SARS-CoV-2, Coronavirus |
| الوصف: | Background: The multi-morbid burden and use of systemic immunosuppressants in people with psoriasis may confer greater risk of adverse COVID-19 outcomes but data are limited. Objective: Characterize the course of COVID-19 in psoriasis and identify factors associated with hospitalization. Methods: Clinicians reported psoriasis patients with confirmed/suspected COVID-19 via an international registry, PsoProtect. Multiple logistic regression assessed the association between clinical/demographic characteristics and hospitalization. A separate patient-facing registry characterized risk-mitigating behaviours. Results: Of 374 clinician-reported patients from 25 countries, 71% were receiving a biologic, 18% a non-biologic and 10% no systemic treatment for psoriasis. 348 (93%) fully recovered from COVID-19, 77 (21%) were hospitalized and nine (2%) died. Increased hospitalization risk was associated with older age (multivariable-adjusted OR 1.59 per 10 years, 95% CI 1.19-2.13), male sex (OR 2.51, 95% CI 1.23-5.12), non-white ethnicity (OR 3.15, 95% CI 1.24- 8.03) and comorbid chronic lung disease (OR 3.87, 95% CI 1.52-9.83). Hospitalization was more frequent in patients using non-biologic systemic therapy than biologics (OR 2.84, 95% CI 1.31-6.18). No significant differences were found between biologic classes. Independent patient-reported data (n=1,626 across 48 countries) suggested lower levels of social isolation in individuals receiving non-biologic systemic therapy compared to biologics (OR 0.68, 95% CI 0.50-0.94). Conclusion: In this international moderate-severe psoriasis case series, biologics use was associated with lower risk of COVID-19-related hospitalization than non-biologic systemic therapies, however further investigation is warranted due to potential selection bias and unmeasured confounding. Established risk factors (being older, male, non-white ethnicity, comorbidities) were associated with higher hospitalization rates. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 34 páginas; application/pdf |
| اللغة: | English |
| تدمد: | 0091-6749 |
| العلاقة: | https://doi.org/10.1016/j.jaci.2020.10.007Test; http://hdl.handle.net/20.500.12010/14764Test |
| DOI: | 10.1016/j.jaci.2020.10.007 |
| الإتاحة: | https://doi.org/20.500.12010/14764Test https://doi.org/10.1016/j.jaci.2020.10.007Test https://hdl.handle.net/20.500.12010/14764Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Abierto (Texto Completo) |
| رقم الانضمام: | edsbas.1F8A0B02 |
| قاعدة البيانات: | BASE |
| تدمد: | 00916749 |
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| DOI: | 10.1016/j.jaci.2020.10.007 |