دورية أكاديمية
A circuit perspective on narcolepsy
| العنوان: | A circuit perspective on narcolepsy |
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| المؤلفون: | Adamantidis, Antoine R., Schmidt, Markus H., Matt Carter, Matt E., Burdakov, Denis, Peyron, C., Scammell, Thomas E. |
| المصدر: | Sleep, 43 (5) |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2020 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | narcolepsy, cataplexy, hypocretins/orexins, neural circuits |
| الوصف: | The sleep disorder narcolepsy is associated with symptoms related to either boundary state control that include excessive daytime sleepiness and sleep fragmentation, or rapid eye movement (REM) sleep features including cataplexy, sleep paralysis, hallucinations, and sleep-onset REM sleep events (SOREMs). Although the loss of Hypocretin/Orexin (Hcrt/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease. ; ISSN:1550-9109 ; ISSN:0161-8105 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/000538026700020; http://hdl.handle.net/20.500.11850/416235Test |
| DOI: | 10.3929/ethz-b-000416235 |
| الإتاحة: | https://doi.org/20.500.11850/416235Test https://doi.org/10.3929/ethz-b-000416235Test https://doi.org/10.1093/sleep/zsz296Test https://hdl.handle.net/20.500.11850/416235Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| رقم الانضمام: | edsbas.40729028 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000416235 |
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