دورية أكاديمية
Reintroducing Heart Sounds for Early Detection of Acute Myocardial Ischemia in a Porcine Model – Correlation of Acoustic Cardiography With Gold Standard of Pressure-Volume Analysis
| العنوان: | Reintroducing Heart Sounds for Early Detection of Acute Myocardial Ischemia in a Porcine Model – Correlation of Acoustic Cardiography With Gold Standard of Pressure-Volume Analysis |
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| المؤلفون: | Luciani, Marco, Saccocci, Matteo, Kuwata, Shingo, Cesarovic, Nikola, id_orcid:0 000-0001-6744-2928, Lipiski, Miriam, Arand, Patricia, Bauer, Peter, Guidotti, Andrea, Regara, Evelyn, Erne, Paul, Zuber, Michel, Maisano, Francesco |
| المصدر: | Frontiers in Physiology, 10 |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2019 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | Acute coronary syndrome, Acute myocardial ischemia, Heart sound, Hemodynamics, Animal model |
| الوصف: | Background: Acoustic cardiography is a hybrid technique that couples heart sounds recording with ECG providing insights into electrical-mechanical activity of the heart in an unsupervised, non-invasive and inexpensive manner. During myocardial ischemia hemodynamic abnormalities appear in the first minutes and we hypothesize a putative diagnostic role of acoustic cardiography for prompt detection of cardiac dysfunction for future patient management improvement. Methods and Results: Ten female Swiss large white pigs underwent permanent distal coronary occlusion as a model of acute myocardial ischemia. Acoustic cardiography analyses were performed prior, during and after coronary occlusion. Pressure-volume analysis was conducted in parallel as an invasive method of hemodynamic assessment for comparison. Similar systolic and diastolic intervals obtained with the two techniques were significantly correlated [Q to min dP/dt vs. Q to second heart sound (r2 = 0.9583, p < 0.0001), PV diastolic filling time vs. AC perfusion time (r2 = 0.9686, p < 0.0001)]. Indexes of systolic and diastolic impairment correlated with quantifiable features of heart sounds [Tau vs. fourth heart sound Display Value (r2 = 0.2721, p < 0.0001) cardiac output vs. third heart sound Display Value (r2 = 0.0791 p = 0.0023)]. Additionally, acoustic cardiography diastolic time (AUC 0.675, p = 0.008), perfusion time (AUC 0.649, p = 0.024) and third heart sound Display Value (AUC 0.654, p = 0.019) emerged as possible indicators of coronary occlusion. Finally, these three parameters, when joined with heart rate into a composite joint-index, represent the best model in our experience for ischemia detection (AUC 0.770, p < 0.001). Conclusion: In the rapidly evolving setting of acute myocardial ischemia, acoustic cardiography provided meaningful insights of mechanical dysfunction in a prompt and non-invasive manner. These findings should propel interest in resurrecting this technique for future translational studies as well as reconsidering its ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31507452; http://hdl.handle.net/20.500.11850/388499Test |
| DOI: | 10.3929/ethz-b-000388499 |
| الإتاحة: | https://doi.org/20.500.11850/388499Test https://doi.org/10.3929/ethz-b-000388499Test https://doi.org/10.3389/fphys.2019.01090Test https://hdl.handle.net/20.500.11850/388499Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ ; Creative Commons Attribution 4.0 International |
| رقم الانضمام: | edsbas.476C6DC1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000388499 |
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