دورية أكاديمية
A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy
| العنوان: | A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy |
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| المؤلفون: | Krieger, Miriam, id_orcid:0 000-0002-1914-1220, van de Water, Steven, Folkerts, Michael M., Mazal, Alejandro, Fabiano, Silvia, Bizzocchi, Nicola, Weber, Damien C., Safai, Sairos, Lomax, Antony J. |
| المصدر: | Medical Physics, 49 (3) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | effectiveness model, FLASH, scanned proton therapy |
| الوصف: | Purpose In ultrahigh dose rate radiotherapy, the FLASH effect can lead to substantially reduced healthy tissue damage without affecting tumor control. Although many studies show promising results, the underlying biological mechanisms and the relevant delivery parameters are still largely unknown. It is unclear, particularly for scanned proton therapy, how treatment plans could be optimized to maximally exploit this protective FLASH effect. Materials and Methods To investigate the potential of pencil beam scanned proton therapy for FLASH treatments, we present a phenomenological model, which is purely based on experimentally observed phenomena such as potential dose rate and dose thresholds, and which estimates the biologically effective dose during FLASH radiotherapy based on several parameters. We applied this model to a wide variety of patient geometries and proton treatment planning scenarios, including transmission and Bragg peak plans as well as single- and multifield plans. Moreover, we performed a sensitivity analysis to estimate the importance of each model parameter. Results Our results showed an increased plan-specific FLASH effect for transmission compared with Bragg peak plans (19.7% vs. 4.0%) and for single-field compared with multifield plans (14.7% vs. 3.7%), typically at the cost of increased integral dose compared to the clinical reference plan. Similar FLASH magnitudes were found across the different treatment sites, whereas the clinical benefits with respect to the clinical reference plan varied strongly. The sensitivity analysis revealed that the threshold dose as well as the dose per fraction strongly impacted the FLASH effect, whereas the persistence time only marginally affected FLASH. An intermediate dependence of the FLASH effect on the dose rate threshold was found. Conclusions Our model provided a quantitative measure of the FLASH effect for various delivery and patient scenarios, supporting previous assumptions about potentially promising planning approaches for FLASH proton therapy. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/000747860300001; http://hdl.handle.net/20.500.11850/530596Test |
| DOI: | 10.3929/ethz-b-000530596 |
| الإتاحة: | https://doi.org/20.500.11850/530596Test https://doi.org/10.3929/ethz-b-000530596Test https://doi.org/10.1002/mp.15459Test https://hdl.handle.net/20.500.11850/530596Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| رقم الانضمام: | edsbas.B22CE084 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000530596 |
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