دورية أكاديمية
Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes
| العنوان: | Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes |
|---|---|
| المؤلفون: | Chouchane, Malek, Melo de Farias, Ana Raquel, de Sousa Moura, Daniela Maria, Hilscher, Markus Michael, Schroeder, Timm, Naves Leaõ, Richardson, Costa, Marcos Romualdo |
| المصدر: | Stem Cell Reports, 9 (1) |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2017 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | lineage reprogramming, induced neurons, proneural genes, astroglial cells, cerebral cortex, cerebellum, cell transplantation |
| الوصف: | Astroglial cells isolated from the rodent postnatal cerebral cortex are particularly susceptible to lineage reprogramming into neurons. However, it remains unknown whether other astroglial populations retain the same potential. Likewise, little is known about the fate of induced neurons (iNs) in vivo. In this study we addressed these questions using two different astroglial populations isolated from the postnatal brain reprogrammed either with Neurogenin-2 (Neurog2) or Achaete scute homolog-1 (Ascl1). We show that cerebellum (CerebAstro) and cerebral cortex astroglia (CtxAstro) generates iNs with distinctive neurochemical and morphological properties. Both astroglial populations contribute iNs to the olfactory bulb following transplantation in the postnatal and adult mouse subventricular zone. However, only CtxAstro transfected with Neurog2 differentiate into pyramidal-like iNs after transplantation in the postnatal cerebral cortex. Altogether, our data indicate that the origin of the astroglial population and transcription factors used for reprogramming, as well as the region of integration, affect the fate of iNs. ; ISSN:2213-6711 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/000405178400016; http://hdl.handle.net/20.500.11850/191543Test |
| DOI: | 10.3929/ethz-b-000191543 |
| الإتاحة: | https://doi.org/20.500.11850/191543Test https://doi.org/10.3929/ethz-b-000191543Test https://doi.org/10.1016/j.stemcr.2017.05.009Test https://hdl.handle.net/20.500.11850/191543Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| رقم الانضمام: | edsbas.1E755794 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000191543 |
|---|