دورية أكاديمية
H3K18 lactylation marks tissue-specific active enhancers
| العنوان: | H3K18 lactylation marks tissue-specific active enhancers |
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| المؤلفون: | Galle, Eva, id_orcid:0 000-0001-9276-2552, Wong, Chee-Wai, Ghosh, Adhideb, id_orcid:0 000-0002-5160-4571, Desgeorges, Thibaut, id_orcid:0 000-0001-9358-1155, Melrose, Kate, Hinte, Laura, id_orcid:0 000-0002-4226-0009, Castellano Castillo, Daniel, id_orcid:0 000-0001-8041-8244, Engl, Magdalena, Agostinho de Sousa, João Pedro, id_orcid:0 000-0001-8124-6624, Ruiz-Ojeda, Francisco Javier, De Bock, Katrien, id_orcid:0 000-0001-8232-4663, Ruiz, Jonatan R., von Meyenn, Ferdinand, id_orcid:0 000-0001-9920-3075 |
| المصدر: | Genome Biology, 23 (1) |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2022 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | Lactylation, H3K18la, Lactate, Epigenetics, Embryonic stem cell, Muscle, Macrophage, Adipocyte, CUT&Tag, ChromHMM, Histone post-translational modification, Promoter, Enhancer |
| الوصف: | Background: Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation. Results: Given the expected relevance of this modification and current limited knowledge of its function, we generate genome-wide datasets of H3K18la distribution in various in vitro and in vivo samples, including mouse embryonic stem cells, macrophages, adipocytes, and mouse and human skeletal muscle. We compare them to profiles of well-established histone modifications and gene expression patterns. Supervised and unsupervised bioinformatics analysis shows that global H3K18la distribution resembles H3K27ac, although we also find notable differences. H3K18la marks active CpG island-containing promoters of highly expressed genes across most tissues assessed, including many housekeeping genes, and positively correlates with H3K27ac and H3K4me3 as well as with gene expression. In addition, H3K18la is enriched at active enhancers that lie in proximity to genes that are functionally important for the respective tissue. Conclusions: Overall, our data suggests that H3K18la is not only a marker for active promoters, but also a mark of tissue specific active enhancers. ; ISSN:1474-760X |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/000865252500001; info:eu-repo/grantAgreement/EC/H2020/803491; http://hdl.handle.net/20.500.11850/576069Test |
| DOI: | 10.3929/ethz-b-000576069 |
| الإتاحة: | https://doi.org/20.500.11850/576069Test https://doi.org/10.3929/ethz-b-000576069Test https://doi.org/10.1186/s13059-022-02775-yTest https://hdl.handle.net/20.500.11850/576069Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ ; Creative Commons Attribution 4.0 International |
| رقم الانضمام: | edsbas.732BDA2D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000576069 |
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