دورية أكاديمية
Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior
| العنوان: | Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior |
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| المؤلفون: | Sarria, Ignacio, Pahlberg, Johan, Cao, Yan, Kolesnikov, Alexander V, Kefalov, Vladimir J, Sampath, Alapakkam P, Martemyanov, Kirill A |
| المساهمون: | National Institutes of Health (NIH) |
| المصدر: | eLife ; volume 4 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2015 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | In the retina, synaptic transmission between photoreceptors and downstream ON-bipolar neurons (ON-BCs) is mediated by a GPCR pathway, which plays an essential role in vision. However, the mechanisms that control signal transmission at this synapse and its relevance to behavior remain poorly understood. In this study we used a genetic system to titrate the rate of GPCR signaling in ON-BC dendrites by varying the concentration of key RGS proteins and measuring the impact on transmission of signal between photoreceptors and ON-BC neurons using electroretinography and single cell recordings. We found that sensitivity, onset timing, and the maximal amplitude of light-evoked responses in rod- and cone-driven ON-BCs are determined by different RGS concentrations. We further show that changes in RGS concentration differentially impact visually guided-behavior mediated by rod and cone ON pathways. These findings illustrate that neuronal circuit properties can be modulated by adjusting parameters of GPCR-based neurotransmission at individual synapses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.06358 |
| DOI: | 10.7554/eLife.06358 |
| الإتاحة: | https://doi.org/10.7554/elife.06358Test https://cdn.elifesciences.org/articles/06358/elife-06358-v2.pdfTest https://cdn.elifesciences.org/articles/06358/elife-06358-v2.xmlTest https://elifesciences.org/articles/06358Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.942F945C |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.06358 |
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