دورية أكاديمية
Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor
| العنوان: | Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor |
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| المؤلفون: | Villarroya, Mercedes, Gandía, Luis, López, Manuela G., García, Antonio G., Cueto, Sénida, García Navío, José Luis, Álvarez-Builla Gómez, Julio |
| المساهمون: | Universidad de Alcalá. Departamento de Química Orgánica |
| بيانات النشر: | Pergamon |
| سنة النشر: | 1996 |
| المجموعة: | e_Buah - Biblioteca Digital de la Universidad de Alcalá |
| مصطلحات موضوعية: | Bovine chromaffin cells, Calcium channels, FTX, Separation, Toxin, Biochemistry & Molecular Biology, Ciencia, Química orgánica, Science, Chemistry, organic |
| الوصف: | Taking as models the polyamine toxin fraction FTX from the funnel-web spider venom, and the guanidinium moiety of guanethidine, a series of azaalkane-1,omega-diguanidinium salts were obtained. Some of them blocked ion fluxes through the neuronal nicotinic receptors for acetylcholine (nAChR). The blockade was exerted at submicromolar concentrations, suggesting a highly selective interaction with the nAChR. In fact, the active compounds on the nAChR ion channel did not recognize the voltage-dependent Na+ or Ca2+ channels of bovine adrenal chromaffin cells. Therefore, these compounds may be useful tools to clarify the functions of nAChR receptors in the central and peripheral nervous systems. ; Fundación Ramón Areces ; Ministerio de Educación y Ciencia |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0968-0896 |
| العلاقة: | http://dx.doi.org/10.1016/0968-0896Test(96)00108-3; info:eu-repo/grantAgreement/MEC//PM92-0039/ES/PLASTICIDAD DE LA CELULA CROMAFIN CO-CULTIVADA CON ASTROGLIA; info:eu-repo/grantAgreement/MEC//PB94-0150/ES; Bioorganic & Medicinal Chemistry, 1996, v.4, n.8, p.1177-1183; http://hdl.handle.net/10017/3513Test |
| DOI: | 10.1016/0968-0896(96)00108-3 |
| الإتاحة: | https://doi.org/10.1016/0968-0896Test(96)00108-3 http://hdl.handle.net/10017/3513Test |
| حقوق: | © Elsevier, 1996 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C3B5EA97 |
| قاعدة البيانات: | BASE |
| تدمد: | 09680896 |
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| DOI: | 10.1016/0968-0896(96)00108-3 |