رسالة جامعية
Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus ; Untersuchungen zum Antagonism zwischen IL-4 und IL-10 an Colitis und einer Helminthen-Infektion in Mus musculus
| العنوان: | Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus ; Untersuchungen zum Antagonism zwischen IL-4 und IL-10 an Colitis und einer Helminthen-Infektion in Mus musculus |
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| المؤلفون: | Specht, Sabine |
| المساهمون: | Hoerauf, Achim (Prof. Dr.) |
| بيانات النشر: | Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky |
| سنة النشر: | 2005 |
| المجموعة: | E-Dissertationen der Universität Hamburg |
| مصطلحات موضوعية: | Th1, Th2, Treg, mouse model, colitis, filariasis, IL-4, IL-10, 570 Biowissenschaften, Biologie, 42.36 Parasitologie, 42.63 Tierphysiologie, Hausmaus, Interleukin 4, Interleukin 10, Antibiotika-assoziierte Colitis, Filariose, ddc:570 |
| الوصف: | The dichotomy of T helper cell immune responses developing into the Th1 type and Th2 type, has been a very powerful means to understand the different pathways that the immune system uses to defend the host against different pathogens and tumors. Intracellular pathogens are usually controlled by Th1 type responses, while extracellular pathogens such as helminths are generally believed to be controlled by Th2. The majority of autoimmune diseases is thought to be due to a Th1 type over-reaction, while allergic diseases are seen as Th2 response against non-harmful environmental antigens. Over the last years, it has become clear that this dichotomy was not sufficient to explain the phenomena of suppression against autoimmunity or tumor immunity on one hand, and of immunosuppression against helminths or the mechanisms of hyposensibilisation against allergens on the other hand. In addition, one has to consider the so-called regulatory T cell responses. Regulatory T cells are characterized by low proliferation and production of IL-10 or TGF-beta. While not all subtypes of regulatory T-cells need IL-10 for their immunosuppressive action, in many situations IL-10-dependent regulatory pathways inhibit both Th1 and Th2 type immune responses. These hypotheses would require that in some situations of autoimmunity, allergy and helminth infections, when Th2 responses are suppressed by regulatory pathways, the respective hallmark cytokines IL-4 and IL-10 will have antagonistic effects. However, direct evidence of such an antagonism has so far not been provided. In the work that led to the present thesis, antagonistic effects of IL-4 and IL-10 in two immunological model situations could be demonstrated, by using mice that have a double deficiency for both IL-4 and IL-10, in comparison to the single knockout mice. In the first model, murine colitis that regularly develops in IL-10 knockout mice, the previous assumption that this pathology is Th1-driven would have argued that the additional knockout of IL-4 in the double knockout ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | English |
| العلاقة: | Specht, S. et al., Infect. Immun., 72, 11, 6287-93, 2004; http://nbn-resolving.de/urn:nbn:de:gbv:18-25229Test; https://ediss.sub.uni-hamburg.de/handle/ediss/998Test |
| الإتاحة: | http://nbn-resolving.de/urn:nbn:de:gbv:18-25229Test https://ediss.sub.uni-hamburg.de/handle/ediss/998Test |
| حقوق: | http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess ; No license |
| رقم الانضمام: | edsbas.373ED330 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |