رسالة جامعية
CT evaluation of tumor response to induction chemotherapy for T3 laryngeal squamous cell carcinoma. Comparison to vocal cord remobilization ; Évaluation tomodensitométrique de la réponse à la chimiothérapie d’induction des carcinomes épidermoïdes T3 du larynx. Comparaison à la remobilisation des cordes vocales
| العنوان: | CT evaluation of tumor response to induction chemotherapy for T3 laryngeal squamous cell carcinoma. Comparison to vocal cord remobilization ; Évaluation tomodensitométrique de la réponse à la chimiothérapie d’induction des carcinomes épidermoïdes T3 du larynx. Comparaison à la remobilisation des cordes vocales |
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| المؤلفون: | Garcia, Gabriel |
| المساهمون: | Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), François Bidault |
| المصدر: | https://dumas.ccsd.cnrs.fr/dumas-01729664Test ; Médecine humaine et pathologie. 2017. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2017 |
| المجموعة: | DUMAS (Dépôt Universitaire de Mémoires Après Soutenance) |
| مصطلحات موضوعية: | Vocal cord remobilization, WHO criteria, Volume evaluation, computed tomography, Cancer laryngé, Remobilisation cordale, RECIST 1.1, Critères OMS, Evaluation volumique, Chimiothérapie d’induction, Tomodensitométrie, Scanner, MESH: Laryngeal Neoplasms, MESH: World Health Organization, MESH: Induction Chemotherapy, MESH: Tomography, MESH: X-Ray Computed, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Objective: after induction chemotherapy for head and neck cancer, CT is used to assess tumor response but lacks rationalized methods for measurement. In T3 laryngeal cancer, vocal cord remobilization is a major sign of tumor response. We compared the performances of RECIST 1.1, WHO and volumetric methods of evaluating response with laryngeal remobilization. Materials and Methods: neck CT-scans were acquired before and after induction chemotherapy from patients treated for T3 laryngeal cancer with initial vocal cord fixation. Tumor size was assessed according to RECIST 1.1, WHO, and volumetric methods. Tumor shrinkage on CT was compared to vocal cord remobilization. Areas under the curve (AUC) of ROC curves were compared and sensitivity and specificity of optimal cutoffs for CT prediction of vocal fold remobilization were determined. Results: Forty-three patients were included; vocal cord remobilization was observed in 24/43 after chemotherapy. AUCs were 0.763 (95%CI [0.615; 0.911]) for RECIST 1.1, 0.779 (95%CI [0.63; 0.971]) for WHO and 0.763 (95%CI [0.623; 0.904]) for volumetric evaluations with no significant difference. Optimal cutoffs for prediction of vocal fold remobilization were - 29% (Se = 70.8%; Sp =68.4%), - 47% (Se = 91.7%; Sp = 63.2%) and - 64% (Se = 75%; Sp = 63.2%) for RECIST 1.1, WHO and volumetric evaluation respectively. Conclusion: RECIST 1.1, WHO or volumetric measurements with CT-scanner match with vocal cord remobilization after induction chemotherapy in patient with T3 laryngeal cancer. Cutoffs were very close to the thresholds corresponding to “partial response” in these evaluation methods and could be confirm in prospective studies. ; Objectif : les méthodes de mesure par tomodensitométrie (TDM), utilisée pour évaluer la réponse tumorale après chimiothérapie d’induction (CI) pour carcinome épidermoïde (CE) T3 du larynx, manquent de standardisation. Dans ces tumeurs, la remobilisation des cordes vocales (RCV) est un signe majeur de réponse. Nous avons comparé les performances de trois ... |
| نوع الوثيقة: | master thesis |
| اللغة: | French |
| العلاقة: | dumas-01729664; https://dumas.ccsd.cnrs.fr/dumas-01729664Test; https://dumas.ccsd.cnrs.fr/dumas-01729664/documentTest; https://dumas.ccsd.cnrs.fr/dumas-01729664/file/ThExe_GARCIA_Gabriel_DUMAS.pdfTest |
| الإتاحة: | https://dumas.ccsd.cnrs.fr/dumas-01729664Test https://dumas.ccsd.cnrs.fr/dumas-01729664/documentTest https://dumas.ccsd.cnrs.fr/dumas-01729664/file/ThExe_GARCIA_Gabriel_DUMAS.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-saTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FB7433D7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |