رسالة جامعية
Clinical features and outcome of influenza pneumonia in critically-ill immunocompromised patients
| العنوان: | Clinical features and outcome of influenza pneumonia in critically-ill immunocompromised patients |
|---|---|
| المؤلفون: | Raymond, Matthieu |
| المساهمون: | Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Emmanuel Canet |
| المصدر: | https://dumas.ccsd.cnrs.fr/dumas-03719314Test ; Médecine humaine et pathologie. 2022. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2022 |
| المجموعة: | DUMAS (Dépôt Universitaire de Mémoires Après Soutenance) |
| مصطلحات موضوعية: | Grippe, Immunosuppression, Réanimation, Pneumonie, Thèses et écrits académiques, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Background: Immunocompromised patients are at risk of severe viral infections which may require ICU admission. Data on the outcome of influenza pneumonia in critically-ill immunocompromised patients are limited. Methods: We conducted a single-center observational study. All patients admitted to the ICU for influenza pneumonia between 2016 and 2020 were included. The main objective was to compare the clinical features and outcome of critically-ill patients with flu according to their immune status. Results: 137 patients (age 60 years-old, 58.4% male) were included, of whom 58 (42.34%) were intubated during ICU stay. 43 (31.4%) patients were immunocompromised. Immunocompromised patients were older and had a higher Charlson comorbidity index. In contrast, severity scores and hypoxemia at admission, and ventilatory support during ICU stay were similar between the 2 groups. There was no difference in the rate of co-infection and ventilator-associated pneumonia between the 2 groups. Among intubated patients, 10 (58.3%) immunocompromised patients developed severe ARDS compared to 13 (32.5%) non-immunocompromised (p=0.02). ICU mortality was 13.97%, with mortality being three-times higher in immunocompromised patients (25.58% versus 8.6%, p=0.015). On multivariable analysis, immunocompromised status, higher age and lower PaO2/FiO2 were associated with an increased ICU mortality. Conclusion: Immunocompromised patients with severe influenza pneumonia were more likely to develop severe ARDS and had a 3-fold increase in ICU mortality compared to non-immunocompromised patients. Such difference was not explained by an increased rate of co-infections/nosocomial pneumonia, suggesting that influenza virus was by itself responsible of a more severe form of pulmonary disease in immunocompromised patients. ; Introduction : Les patients immunodéprimés sont à risque d'infections virales sévères. Cependant, les données sur le devenir des patients immunodéprimés atteints de grippe et nécessitant une prise en charge en réanimation sont ... |
| نوع الوثيقة: | master thesis |
| اللغة: | French |
| العلاقة: | dumas-03719314; https://dumas.ccsd.cnrs.fr/dumas-03719314Test; https://dumas.ccsd.cnrs.fr/dumas-03719314/documentTest; https://dumas.ccsd.cnrs.fr/dumas-03719314/file/RaymondMED22.pdfTest; PPN: 263444554 |
| الإتاحة: | https://dumas.ccsd.cnrs.fr/dumas-03719314Test https://dumas.ccsd.cnrs.fr/dumas-03719314/documentTest https://dumas.ccsd.cnrs.fr/dumas-03719314/file/RaymondMED22.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.B15DB605 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |