دورية أكاديمية
Very low-carbohydrate high-fat diet improves risk markers for cardiometabolic health more than exercise in men and women with overfat constitution: Secondary analysis of a randomized controlled clinical trial
| العنوان: | Very low-carbohydrate high-fat diet improves risk markers for cardiometabolic health more than exercise in men and women with overfat constitution: Secondary analysis of a randomized controlled clinical trial |
|---|---|
| المؤلفون: | Cipryan, Lukáš, Litschmannová, Martina, Maffetone, Philip B., Plews, Daniel J., Dostál, Tomáš, Hofmann, Peter, Laursen, Paul B. |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | DSpace VŠB-TUO (Vysoká škola báňská - Technická univerzita Ostrava / Technical University of Ostrava) |
| مصطلحات موضوعية: | HOMA-IR, adiponectin, leptin, TG/HDL-C, TyG index, low carbohydrate diet, exercise, overfat |
| الوصف: | Purpose: This randomized controlled parallel-group study examined the effects of a very low-carbohydrate high-fat (VLCHF) diet and high-intensity interval training (HIIT) program over 12-weeks on cardiometabolic risk factors in individuals with overfat constitution. Methods: Ninety-one participants out of 109 completed the study. The participants were randomly allocated to the HIIT (N = 22), VLCHF (N = 25), VLCHF+HIIT (N = 25), or control (N = 19) groups for 12 weeks. Fasting plasma samples were collected before the intervention and after 4 and 12 weeks. The analyzed outcomes included complete blood count, glucose, insulin, glycated hemoglobin, triglycerides (TG), cholesterol, high- and low-density lipoprotein (HDL-C and LDL-C), lipoprotein(a), adiponectin (Adpn), leptin (Lep), tumor necrosis factor alpha (TNF-alpha), other interleukins (hs-IL-6, IL-1 beta, and IL-10), and IL-1RA. The homeostasis model assessment of insulin resistance (HOMA-IR), Adpn/Lep ratio, TG/HDL-C ratio, and TyG index were calculated and analyzed. Blood pressure was measured before the intervention, after 4, 8, and 12 weeks (: NCT03934476). Results: Absolute changes in HOMA-IR, Adpn/Lep ratio, LDL-C, and diastolic blood pressure after 12 weeks differed by study groups (p < 0.05). The most pronounced changes were revealed in the VLCHF (& UDelta;M [95% CI]; HOMA-IR: -0.75 [-1.13; -0.55]; Adpn/Lep: 9.34 [6.33; 37.39]; LDL-C: 0.06 [-0.12; 0.50] mmol/l) and VLCHF+HIIT (HOMA-IR: -0.44 [-1.14; 0.12]; Adpn/Lep: 4.26 [2.24; 13.16]; LDL-C: 0.25 [-0.04; 0.50] mmol/l) groups. Conclusions: A 12-week VLCHF diet intervention in individuals with overfat constitution is effective for favorable changes in HOMA-IR (compared to HIIT), Adpn/Lep ratio, and diastolic blood pressure. HIIT, or HIIT combined with the VLCHF diet, had no additional benefits for the analyzed variables. No adverse side effects were observed. ; Web of Science ; 9 ; art. no. 867690 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2296-861X |
| العلاقة: | Frontiers in Nutrition; https://doi.org/10.3389/fnut.2022.867690Test; Frontiers in Nutrition. 2022, vol. 9, art. no. 867690.; http://hdl.handle.net/10084/148595Test; 000807327300001 |
| DOI: | 10.3389/fnut.2022.867690 |
| الإتاحة: | https://doi.org/10.3389/fnut.2022.867690Test http://hdl.handle.net/10084/148595Test |
| حقوق: | Copyright © 2022 Cipryan, Litschmannova, Maffetone, Plews, Dostal, Hofmann and Laursen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ; http://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.64AD15CF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296861X |
|---|---|
| DOI: | 10.3389/fnut.2022.867690 |