دورية أكاديمية
Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells
| العنوان: | Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells |
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| المؤلفون: | Juan, Aster H., Wang, Stan, Ko, Kyung Dae, Zare, Hossein, Tsai, Pei-Fang, Feng, Xuesong, Ascoli, Anthony M., Gutierrez-Cruz, Gustavo, Krebs, Jordan, Sidoli, Simone, Knight, Adam L., Pedersen, Roger A., Garcia, Benjamin A., Casellas, Rafael, Zou, Jizhong, Sartorelli, Vittorio, Vivanco, Karinna O. |
| المساهمون: | Massachusetts Institute of Technology. Department of Biological Engineering, Vivanco, Karinna O. |
| المصدر: | Elsevier |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2016 |
| المجموعة: | DSpace@MIT (Massachusetts Institute of Technology) |
| الوصف: | The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27 methylation have different functions. In this study, we have generated isogenic mouse embryonic stem cells (ESCs) with a modified H3K27me2/H3K27me3 ratio. Our findings document dynamic developmental control in the genomic distribution of H3K27me2 and H3K27me3 at regulatory regions in ESCs. They also reveal that modifying the ratio of H3K27me2 and H3K27me3 is sufficient for the acquisition and repression of defined cell lineage transcriptional programs and phenotypes and influences induction of the ESC ground state. ; National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.). Intramural Research Program |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2211-1247 |
| العلاقة: | http://dx.doi.org/10.1016/j.celrep.2016.09.087Test; Cell Reports; http://hdl.handle.net/1721.1/107488Test; Juan, Aster H. et al. “Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells.” Cell Reports 17.5 (2016): 1369–1382. © 2017 Elsevier |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2016.09.087Test http://hdl.handle.net/1721.1/107488Test |
| حقوق: | Creative Commons Attribution-NonCommercial-NoDerivs License ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.2E360FD0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22111247 |
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