دورية أكاديمية
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
| العنوان: | The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring |
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| المؤلفون: | Choi, Gloria, Yim, Yeong Shin, Wong, Helen, Kim, Sangdoo, Kim, Hyunju, Kim, Sangwon V., Hoeffer, Charles A., Littman, Dan R., Huh, Jun R. |
| المساهمون: | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Choi, Gloria, Yim, Yeong Shin |
| المصدر: | PMC |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2016 |
| المجموعة: | DSpace@MIT (Massachusetts Institute of Technology) |
| الوصف: | Viral infection during pregnancy has been correlated with increased frequency of autism spectrum disorder (ASD) in offspring. This observation has been modeled in rodents subjected to maternal immune activation (MIA). The immune cell populations critical in the MIA model have not been identified. Using both genetic mutants and blocking antibodies in mice, we show that retinoic acid receptor–related orphan nuclear receptor gamma t (RORγt)–dependent effector T lymphocytes [for example, T helper 17 (T[subscript H]17) cells] and the effector cytokine interleukin-17a (IL-17a) are required in mothers for MIA-induced behavioral abnormalities in offspring. We find that MIA induces an abnormal cortical phenotype, which is also dependent on maternal IL-17a, in the fetal brain. Our data suggest that therapeutic targeting of T[subscript H]17 cells in susceptible pregnant mothers may reduce the likelihood of bearing children with inflammation-induced ASD-like phenotypes. ; Massachusetts Institute of Technology. Simons Center for the Social Brain |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0036-8075 1095-9203 |
| العلاقة: | http://dx.doi.org/10.1126/science.aad0314Test; Science; http://hdl.handle.net/1721.1/102363Test; Choi, G. B., Y. S. Yim, H. Wong, S. Kim, H. Kim, S. V. Kim, C. A. Hoeffer, D. R. Littman, and J. R. Huh. “The Maternal Interleukin-17a Pathway in Mice Promotes Autism-Like Phenotypes in Offspring.” Science 351, no. 6276 (January 28, 2016): 933–939.; orcid:0000-0001-9196-7302 |
| الإتاحة: | https://doi.org/10.1126/science.aad0314Test http://hdl.handle.net/1721.1/102363Test |
| حقوق: | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. |
| رقم الانضمام: | edsbas.15F61D61 |
| قاعدة البيانات: | BASE |
| تدمد: | 00368075 10959203 |
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