دورية أكاديمية
Circle of Willis anomalies in Turner syndrome: Absent A1 segment of the anterior cerebral artery
| العنوان: | Circle of Willis anomalies in Turner syndrome: Absent A1 segment of the anterior cerebral artery |
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| المؤلفون: | Kruszka, Paul, Buscetta, Ashley, Acosta, Maria T., Banks, Nicole, Addissie, Yonit A., Toro, Camilo, Luby, Marie, Latour, Lawrence, Vezina, Gilbert, Page, David C, Muenke, Maximilian |
| المساهمون: | Massachusetts Institute of Technology. Department of Biology |
| المصدر: | Prof. Page via Courtney Crummett |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | DSpace@MIT (Massachusetts Institute of Technology) |
| الوصف: | Purpose: Turner syndrome (TS) is the most common sex chromosome disorder in women and is associated with a higher than expected death rate secondary to cerebrovascular disease, including stroke. This study evaluates the cerebral vascular anatomy of individuals with TS. Methods: Twenty-one women with TS had brain magnetic resonance angiography (MRA). These MRAs were evaluated in a blinded manner with a control group of 25 men and 25 women who had MRA imaging for multiple indications including migraine headaches, psychiatric disorders, and seizures. Results: Twenty-nine percent of women with TS were missing an A1 segment of the anterior cerebral artery (ACA) compared to 0% in the control group (p <.001). There were no other significant differences in the circle of Willis (COW) in women with TS compared with the control group. A complete COW was found in 3 of 21 (14%) of women with TS and 12 of 47 (26%) controls (p =.36). Conclusion: Women with TS have a significantly different intracranial vascular anatomy, specifically the absence of the A1 segment of the ACA when compared to male and female controls. More research in brain imaging in women with TS and stroke and other cerebrovascular diseases is needed to determine the clinical significance of this anomaly. ; National Human Genome Research Institute (Grant 1U01HG007587-01A1) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2472-1727 |
| العلاقة: | http://dx.doi.org/10.1002/bdr2.1609Test; Birth Defects Research; https://hdl.handle.net/1721.1/126421Test; Kruszka, Paul et al. "Circle of Willis anomalies in Turner syndrome: Absent A1 segment of the anterior cerebral artery." Birth Defects Research 111, 19 (October 2019): 1584-1588 © 2019 Wiley Periodicals |
| الإتاحة: | https://doi.org/10.1002/bdr2.1609Test https://hdl.handle.net/1721.1/126421Test |
| حقوق: | Creative Commons Attribution-Noncommercial-Share Alike ; http://creativecommons.org/licenses/by-nc-sa/4.0Test/ |
| رقم الانضمام: | edsbas.6F796BFB |
| قاعدة البيانات: | BASE |
| تدمد: | 24721727 |
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