دورية أكاديمية
Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage
| العنوان: | Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage |
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| المؤلفون: | Huang, Sha, Hou, Han Wei, Kanias, Tamir, Sertorio, Jonas Tadeu, Chen, Huichao, Sinchar, Derek, Gladwin, Mark T., Han, Jongyoon |
| المساهمون: | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Huang, Sha, Hou, Han Wei, Han, Jongyoon |
| المصدر: | PMC |
| بيانات النشر: | Royal Society of Chemistry, The |
| سنة النشر: | 2014 |
| المجموعة: | DSpace@MIT (Massachusetts Institute of Technology) |
| الوصف: | In this study, the effects of prolonged storage on several biophysical properties of red blood cells (RBCs) were investigated. Single cell deformability was used as an important criterion in determining subgroups of RBCs evolved during storage lesion. A deformability-based microfluidic cell sorting technology was applied, which demonstrates the ability to enrich and separate the less deformable subpopulations of stored blood. These less deformable RBC subpopulations were then associated with other important markers such as osmotic fragility indicating cell integrity as well as microparticle content. This work demonstrates a systematic methodology to both monitor and improve banked blood quality, thereby reducing risks related to blood transfusion. ; United States. Defense Advanced Research Projects Agency (N66001-11-1-4182) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1473-0197 1473-0189 |
| العلاقة: | http://dx.doi.org/10.1039/c4lc00768aTest; Lab on a Chip; http://hdl.handle.net/1721.1/110939Test; Huang, Sha et al. “Towards Microfluidic-Based Depletion of Stiff and Fragile Human Red Cells That Accumulate During Blood Storage.” Lab Chip 15, 2 (January 2015): 448–458 © 2015 The Royal Society of Chemistry; orcid:0000-0001-7215-1439 |
| الإتاحة: | https://doi.org/10.1039/c4lc00768aTest http://hdl.handle.net/1721.1/110939Test |
| حقوق: | Creative Commons Attribution-Noncommercial-Share Alike ; http://creativecommons.org/licenses/by-nc-sa/4.0Test/ |
| رقم الانضمام: | edsbas.12AA64D7 |
| قاعدة البيانات: | BASE |
| تدمد: | 14730197 14730189 |
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