دورية أكاديمية
Cystatin-C and TGF-beta levels in patients with diabetic nephropathy
| العنوان: | Cystatin-C and TGF-beta levels in patients with diabetic nephropathy |
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| المؤلفون: | Takir, Mumtaz, Unal, Asli Dogruk, Kostek, Osman, Bayraktar, Nilufer, Demirag, Nilgun Guvener |
| سنة النشر: | 2016 |
| المجموعة: | DSpace@Baskent - Baskent University Institutional Repository |
| مصطلحات موضوعية: | Diabetic nephropathy, Cystatin C, TGF-beta 1, Microalbuminuria, Normoalbuminuria |
| الوصف: | Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-beta levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-beta 1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = -0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = -0.726, p=0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. (C) 2016 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Nefrologia. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0211-6995 |
| العلاقة: | NEFROLOGIA; https://www.sciencedirect.com/science/article/pii/S0211699516301126?via%3DihubTest; http://hdl.handle.net/11727/3610Test; 36; 653; 659; 000392046800009 |
| الإتاحة: | http://hdl.handle.net/11727/3610Test https://www.sciencedirect.com/science/article/pii/S0211699516301126?via%3DihubTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.55B7D3DC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02116995 |
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