دورية أكاديمية
Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
| العنوان: | Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes |
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| المؤلفون: | Colberg,Sheri R, Hill,Laura C, Parson,Henri K, Thomas,Kathleen S, Vinik,Aaron I |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2010 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| الوصف: | Sheri R Colberg1, Laura C Hill2, Henri K Parson3, Kathleen S Thomas1, Aaron I Vinik31Old Dominion University, Norfolk; 2State University of New York at Cortland, New York; 3Eastern Virginia Medical School, Norfolk, VirginiaAbstract: It is well known that a number of locally released vasodilatory and vasoconstrictive compounds can affect skin perfusion. This study investigated the effects of aerobic training on the contribution of nitric oxide (NO), prostaglandins (PG), and endothelial-derived hyperpolarizing factor (EDHF) in stimulated dorsal foot skin perfusion in individuals with type 2 diabetes (T2DM). Ten previously sedentary, older individuals with T2DM (57.0 ± 3.1 years) and nine sedentary controls (53.5 ± 3.2 years) were tested before and after undertaking six months of moderate aerobic training three times weekly in a supervised setting. All subjects underwent measurement of baseline (32°C) and heat-stimulated (40°C and 44°C) dorsal foot skin perfusion starting one hour after ingestion of a single, oral 325 mg dose of aspirin, a known inhibitor of PG synthesis. Before aspirin ingestion, a subcutaneous microdialysis probe was inserted into each foot dorsum to administer either saline (PG pathway only blocked by aspirin in the left foot) or L-NAME (N(G)-nitro-l-arginine methyl ester; thereby inhibiting both PG and NO pathways in the right foot). Normative data collected previously on subjects undergoing saline administration via microdialysis without aspirin ingestion served as a control group. Significantly lower responsiveness of maximal perfusion was found with the EDHF pathway alone unblocked compared with NO and EDHF unblocked after training. Maximal suppression attributable directly to NO, PG, and EDHF was not significantly different when examined by subject group and training status. However, contributions of NO, PG, and EDHF to maximal perfusion were significantly increased, decreased, and unchanged by aerobic training, respectively, with diabetic and control subjects combined due to ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/aerobic-training-increases-skin-perfusion-by-a-nitric-oxide-mechanism--peer-reviewed-fulltext-article-DMSOTest |
| الإتاحة: | https://doi.org/10.2147/DMSO.S12136Test https://www.dovepress.com/aerobic-training-increases-skin-perfusion-by-a-nitric-oxide-mechanism--peer-reviewed-fulltext-article-DMSOTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.55468F2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |