المؤلفون: Sonohata,Motoki, Doi,Atsushi, Uchihashi,Kazuyoshi, Hashimoto,Akira, Kii,Sakumo, Inoue,Takao, Mawatari,Masaaki

مصطلحات موضوعية: Journal of Pain Research

الوصف: Motoki Sonohata,1,2,* Atsushi Doi,3,* Kazuyoshi Uchihashi,4 Akira Hashimoto,2 Sakumo Kii,1 Takao Inoue,5 Masaaki Mawatari1 1Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga, Japan; 2Department of Orthopaedic Surgery, Saga Central Hospital, Saga, Japan; 3Department of Rehabilitation, Kumamoto Health Science University, Kumamoto, Japan; 4Department of Surgical Pathology, National Hospital Organization Saga Hospital, Saga, Japan; 5Organization of Research Initiatives, Yamaguchi University, Yamaguchi, Japan*These authors contributed equally to this workCorrespondence: Atsushi Doi, Department of Rehabilitation, Kumamoto Health Science University, 324, Izumi, Kumamoto-kitaku, Kumamoto, 861-5598, Japan, Tel +81-96-275-2111, Email atsushidoi01@gmail.comPurpose: This study used a sciatic nerve injury rat model to investigate the short-term effects of a polyglycolic acid (PGA)-collagen tube for nerve injury in continuity.Materials and Methods: Sixteen female Wistar rats (6– 8 weeks) were used, and the left sciatic nerve was crushed with a Sugita aneurysm clip. Sciatic nerve model rats were randomly categorized into two groups (n = 8; control group, n = 8; nerve wrapping group). Then, we measured four sensory thresholds, magnetically stimulated the lumbar region to induce motor-evoked potentials (MEPs), and evaluated the sciatic nerve histopathologically.Results: In the sensory thresholds, there were significant differences for the main effect in 250 and 2000 Hz stimulation (p = 0.048 and 0.006, respectively). Further, a significant difference was observed with 2000 Hz stimulation at 1 week (p = 0.003). In the heat stimulation, there were significant differences for the main effect in both weeks and groups (p = 0.0002 and 0.0185, respectively). The post-hoc test showed a significant difference between groups only in 2W (p = 0.0283). Three weeks after the surgery, both 2nd and 3rd MEPs waves-related latencies in the nerve wrapping group were significantly shorter than those in the control ...

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العلاقة: https://www.dovepress.com/short-term-collagen-nerve-wrapping-facilitates-motor-and-sensory-recov-peer-reviewed-fulltext-article-JPRTest

الإتاحة: https://doi.org/10.2147/JPR.S401126
https://www.dovepress.com/short-term-collagen-nerve-wrapping-facilitates-motor-and-sensory-recov-peer-reviewed-fulltext-article-JPRTest

المؤلفون: Sonohata,Motoki, Doi,Atsushi, Yasaka,Toshiharu, Uta,Daisuke, Mawatari,Masaaki, Yoshimura,Megumu

مصطلحات موضوعية: Journal of Pain Research

الوصف: Motoki Sonohata,1 Atsushi Doi,2 Toshiharu Yasaka,3 Daisuke Uta,4 Masaaki Mawatari,1 Megumu Yoshimura5,61Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga, Japan; 2Department of Physical Therapy, Kumamoto Health Science University, Kumamoto, Japan; 3Department of Immunology, Graduate School of Medical and Dental SciencesKagoshima University, Kagoshima, Japan; 4Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan; 5Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 6Nakamura Hospital, Nogata, Fukuoka, JapanPurpose: We investigated the effects of noradrenaline (NA) on physiologically evoked synaptic responses of substantia gelatinosa (SG) neurons using anesthetized animals.Methods: Male Sprague–Dawley rats (6–8 weeks, 200–300 g, n=21) were anesthetized. The lumbar spinal cord was exposed from L3 to L5; subsequently, the rats were fixed to a stereotaxic apparatus. The electrode was advanced at an angle of 30–45 degrees into the SG using a micromanipulator. We recorded excitatory post-synaptic currents (EPSC). Under these conditions, innocuous or noxious mechanical stimuli were applied to the receptive ï¬eld of the ipsilateral hindlimb with or without NA, respectively.Results: NA (50 μM) pre-application induced three types of responses for pinch-evoked EPSCs. The number of neurons showing inhibition, facilitation, and no-effect was 15 (71.4%), 2 (9.5%), and 4 (19%), respectively (n=21). Pre-treatment with NA also induced three different types of responses for puff-evoked EPSC (n=21). The number of neurons showing inhibition, facilitation, and no-effect was 9 (42.9%), 9 (42.9%), and 3 (14.2%), respectively. Further, there was a significant difference in the rate distribution (inhibition, facilitation, and no change) between puff- and pinch-evoked responses.Conclusion: Our present data indicate that NA acts on noxious and innocuous mechanical transmission in ...

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العلاقة: https://www.dovepress.com/noradrenaline-modulates-mechanically-evoked-responses-in-the-rat-spina-peer-reviewed-fulltext-article-JPRTest

الإتاحة: https://doi.org/10.2147/JPR.S181210
https://www.dovepress.com/noradrenaline-modulates-mechanically-evoked-responses-in-the-rat-spina-peer-reviewed-fulltext-article-JPRTest

المؤلفون: Doi,Atsushi, Sakasaki,Juntaro, Tokunaga,Chikato, Sugita,Fumiya, Kasae,Syota, Nishimura,Keisuke, Sato,Yushi, Kuratsu,Takako, Hashiguchi,Sariya, Shin,Min-Chul, Yoshimura,Megumu

مصطلحات موضوعية: Journal of Pain Research

الوصف: Atsushi Doi,1,2,* Juntaro Sakasaki,3,* Chikato Tokunaga,4,* Fumiya Sugita,5,* Syota Kasae,6 Keisuke Nishimura,7 Yushi Sato,8 Takako Kuratsu,9 Sariya Hashiguchi,10 Min-Chul Shin,1,2 Megumu Yoshimura11 1Department of Physical Therapy, Kumamoto Health Science University, Kumamoto, Japan; 2Graduate School of Health Sciences, Kumamoto Health Science University, Kumamoto, Japan; 3Department of Rehabilitation, Tokyo-Wangan Rehabilitation Hospital, Narashino, Japan; 4Department of Rehabilitation, Himeno Hospital, Yame, Japan; 5Department of Rehabilitation, Tamana Central Hospital, Tamana, Japan; 6Department of Rehabilitation, Shimizu Hospital, Kyoto, Japan; 7Department of Rehabilitation, Iizuka Hospital, Iizuka, Japan; 8Department of Rehabilitation, Showa Hospital, Shimonoseki, Japan; 9Department of Rehabilitation, Konan Hospital, Kumamoto, Japan; 10Department of Rehabilitation, Asahino-Sogo Hospital, Kumamoto, Japan; 11Nakamura Hospital, Nogata, Japan *These authors contributed equally to this work Purpose: This study was aimed to investigate the effect of localized vibration on sensory thresholds in mice and humans using a novel quantitative method. Participants and methods: The sensory thresholds of 7-week-old male C57BL/6J mice were measured with four sine-wave electrostimulation frequencies (5, 50, 250, and 2,000 Hz) before and after applying 2-minute vibration to the plantar side of the foot in mice. In human participants (16 males and 16 females; mean age, 21.0±0.8 years), the sensory threshold was measured at 50 Hz before and after applying 2-minute and 5-minute vibrations to the dorsal side of the foot. Results: Application of a 2-minute vibration at either the ipsilateral or contralateral side modulated the sensory thresholds elicited by a 5- or 50-Hz right electrostimulation in mice. In human participants, application of a 5-minute vibration at either the ipsilateral or contralateral side modulated the sensory threshold elicited by 50-Hz right electrostimulation, but had no effect on local skin temperature. ...

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العلاقة: https://www.dovepress.com/both-ipsilateral-and-contralateral-localized-vibratory-stimulations-mo-peer-reviewed-fulltext-article-JPRTest

الإتاحة: https://doi.org/10.2147/JPR.S162379
https://www.dovepress.com/both-ipsilateral-and-contralateral-localized-vibratory-stimulations-mo-peer-reviewed-fulltext-article-JPRTest