دورية أكاديمية
Arginine Biosynthesis Pathway Found to Play a Key Role in the Neuroprotective Effect of Liu-Wei-Luo-Bi (LWLB) Granules in Diabetic db/db Mice with Peripheral Neuropathy Using an Untargeted Metabolomics Strategy
| العنوان: | Arginine Biosynthesis Pathway Found to Play a Key Role in the Neuroprotective Effect of Liu-Wei-Luo-Bi (LWLB) Granules in Diabetic db/db Mice with Peripheral Neuropathy Using an Untargeted Metabolomics Strategy |
|---|---|
| المؤلفون: | Liu,Qiong, Chen,Yafei, Wang,Bo, Chen,Yinying, Li,Bing, Guan,Shuang, Du,Kehe, Liu,Xiaoyang, Yu,Yanan, Liu,Jun, Wang,Zhong |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2023 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | Diabetes, Metabolic Syndrome and Obesity |
| الوصف: | Qiong Liu,1,2 Yafei Chen,1 Bo Wang,1 Yinying Chen,3 Bing Li,4 Shuang Guan,1 Kehe Du,5 Xiaoyang Liu,5 Yanan Yu,1 Jun Liu,1 Zhong Wang1 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Postdoctoral Research Station, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 3Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 4Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 5iPhase Pharma Services, Beijing, People’s Republic of ChinaCorrespondence: Zhong Wang, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China, Email zhonw@vip.sina.comAim: Liu-Wei-Luo-Bi (LWLB) granules was a Chinese compound prescription for treating diabetic peripheral neuropathy (DPN). The aim of this study was to investigate the effect of LWLB granules on diabetic mice with peripheral neuropathy and to elucidate the potential mechanism based on an untargeted metabolomics approach.Methods: One hundred forty db/db mice were randomly divided into seven groups: the Control group, DPN group, Mudan (MD) granules group, Epalrestat (Epa) group, and the LWLB low, medium, or high dose (LW-l, LW-m, or LW-h) group. After 12 weeks of treatment, body weight, blood glucose, mechanical pain threshold, motor conduction velocity (MCV), sensory conduction velocity (SCV), and Pathological Organization of the Sciatic and Caudal Nerves in mice were measured. Serum samples were collected for untargeted metabolomics analysis using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) and multivariate statistics. Disease-related pathways were screened out with function enrichment analyses of candidate biomarkers.Results: LWLB granules can improve the peripheral neuropathy of type 2 diabetic mice with peripheral nerve conduction ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/arginine-biosynthesis-pathway-found-to-play-a-key-role-in-the-neuropro-peer-reviewed-fulltext-article-DMSOTest |
| الإتاحة: | https://doi.org/10.2147/DMSO.S423388Test https://www.dovepress.com/arginine-biosynthesis-pathway-found-to-play-a-key-role-in-the-neuropro-peer-reviewed-fulltext-article-DMSOTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D6101139 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |