دورية أكاديمية
Pronatriodilatin gene polymorphisms, microvascular permeability, and diabetic nephropathy in type 1 diabetes mellitus
| العنوان: | Pronatriodilatin gene polymorphisms, microvascular permeability, and diabetic nephropathy in type 1 diabetes mellitus |
|---|---|
| المؤلفون: | Nannipieri, Monica, Penno, Guiseppe, Pucci, Laura, Colhoun, Helen, Motti, Corradino, Bertacca, Anna, Rizzo, Loredana, De Giorgio, Lamberto, Zerbini, Giampaolo, Mangili, Ruggero, Navalesi, Renzo |
| المصدر: | Nannipieri , M , Penno , G , Pucci , L , Colhoun , H , Motti , C , Bertacca , A , Rizzo , L , De Giorgio , L , Zerbini , G , Mangili , R & Navalesi , R 1999 , ' Pronatriodilatin gene polymorphisms, microvascular permeability, and diabetic nephropathy in type 1 diabetes mellitus ' , Journal of the American Society of Nephrology , vol. 10 , no. 7 , pp. 1530-1541 . < http://jasn.asnjournals.org/content/10/7/1530.fullTest > |
| سنة النشر: | 1999 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| الوصف: | Approximately 30% of diabetic patients develop nephropathy, the appearance of which is partially under genetic control. Atrial natriuretic peptide (ANP) has associated physiologic effects on the kidney. This study was conducted to examine the relationship between a newly identified and known polymorphism at the pronatriodilatin (PND) gene locus and renal involvement in type 1 diabetic subjects. Of 454 type 1 diabetic patients (219 men, 235 women), 323 showed no sign of nephropathy, 79 had incipient renal involvement, and 52 established nephropathy; 58 healthy control subjects were examined for comparison. Allele frequencies (C 708 versus T 708 ) were: 0.95 and 0.05 in normoalbuminuric patients, respectively; 0.88 and 0.12 in microalbuminuric patients; 0.96 and 0.04 both in those with overt nephropathy and in healthy control subjects ( P = 0.011). Patients with incipient nephropathy were in disequilibrium compared with the total diabetic cohort ( P = 0.02). In the same populations, an additional genotype for ScaI polymorphism of the PND gene was tested. The A 1 and A 2 allele frequencies were: 0.21 and 0.79 in normoalbuminuric patients; 0. 13 and 0.87 in microalbuminuric patients; 0.06 and 0.94 in type 1 diabetic subjects with overt nephropathy; and 0.20 and 0.80 in healthy control subjects, respectively ( P <0.0001). A subset of 55 normotensive patients with type 1 diabetes, well matched for clinical features, plasma ANP levels, and microvascular permeability to macromolecules, was investigated on the basis of the C 708 /T and A 2 /A 1 polymorphisms. Both transcapillary escape rate of albumin (TER alb ) and plasma ANP levels were significantly lower in patients with the T708 than with C708 allele, as well as in the A1 than in A2 allele (TER alb : T 708 versus C 708 : 5.5±1.7 versus 7.8±2.0%/h, P = 0.0001; plasma ANP levels: 8.3±3.9 versus 15.3±7.7 pg/ml, P = 0.0003; A1 versus A2: 6.05±2.2 versus 7.3±2.1%/h, P = 0.044; 8.53±4.6 versus 14.5±7.4 pg/ml, P = 0.0024, respectively). Thus, in a large ethnically ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://discovery.dundee.ac.uk/en/publications/12c7d752-1a38-457f-9fc7-3b7000f4efb1Test |
| الإتاحة: | https://discovery.dundee.ac.uk/en/publications/12c7d752-1a38-457f-9fc7-3b7000f4efb1Test http://jasn.asnjournals.org/content/10/7/1530.fullTest |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.8B906FE5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |