المؤلفون: Monahan, Kevin J., Davies, Michael M., Abulafi, Muti, Banerjea, Ayan, Nicholson, Brian D., Arasaradnam, Ramesh, Barker, Neil, Benton, Sally, Booth, Richard, Burling, David, Carten, Rachel Victoria, D'Souza, Nigel, East, James Edward, Kleijnen, Jos, Machesney, Michael, Pettman, Maria, Pipe, Jenny, Saker, Lance, Sharp, Linda, Stephenson, James, Steele, Robert J .C.

المصدر: Monahan , K J , Davies , M M , Abulafi , M , Banerjea , A , Nicholson , B D , Arasaradnam , R , Barker , N , Benton , S , Booth , R , Burling , D , Carten , R V , D'Souza , N , East , J E , Kleijnen , J , Machesney , M , Pettman , M , Pipe , J , Saker , L , Sharp , L , Stephenson , J & Steele , R J C 2022 , ' Faecal immunochemical testing (FIT) in patients ....

الوصف: Faecal immunochemical testing (FIT) has a high sensitivity for the detection of colorectal cancer (CRC). In a symptomatic population FIT may identify those patients who require colorectal investigation with the highest priority. FIT offers considerable advantages over the use of symptoms alone, as an objective measure of risk with a vastly superior positive predictive value for CRC, while conversely identifying a truly low risk cohort of patients. The aim of this guideline was to provide a clear strategy for the use of FIT in the diagnostic pathway of people with signs or symptoms of a suspected diagnosis of CRC. The guideline was jointly developed by the Association of Coloproctology of Great Britain and Ireland/British Society of Gastroenterology, specifically by a 21-member multidisciplinary guideline development group (GDG). A systematic review of 13 535 publications was undertaken to develop 23 evidence and expert opinion-based recommendations for the triage of people with symptoms of a suspected CRC diagnosis in primary care. In order to achieve consensus among a broad group of key stakeholders, we completed an extended Delphi of the GDG, and also 61 other individuals across the UK and Ireland, including by members of the public, charities and primary and secondary care. Seventeen research recommendations were also prioritised to inform clinical management.

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/896b63ad-7ae2-40be-8c0a-f51ad7e2c831Test

الإتاحة: https://doi.org/10.1136/gutjnl-2022-327985Test
https://discovery.dundee.ac.uk/en/publications/896b63ad-7ae2-40be-8c0a-f51ad7e2c831Test
https://discovery.dundee.ac.uk/ws/files/77166542/gutjnl_2022_327985.full.pdfTest

المؤلفون: Crosbie, Emma J., Ryan, Neil A. J., Arends, Mark J., Bosse, Tjalling, Burn, John, Cornes, Joanna M., Crawford, Robin, Eccles, Diana, Frayling, Ian M., Ghaem-Maghami, Sadaf, Hampel, Heather, Kauff, Noah D., Kitchener, Henry C., Kitson, Sarah J., Manchanda, Ranjit, McMahon, Raymond F. T., Monahan, Kevin J., Menon, Usha, Møller, Pål, Möslein, Gabriela, Rosenthal, Adam, Sasieni, Peter, Seif, Mourad W., Singh, Naveena, Skarrott, Pauline, Snowsill, Tristan M., Steele, Robert, Tischkowitz, Marc, Evans, D. Gareth

المصدر: Crosbie , E J , Ryan , N A J , Arends , M J , Bosse , T , Burn , J , Cornes , J M , Crawford , R , Eccles , D , Frayling , I M , Ghaem-Maghami , S , Hampel , H , Kauff , N D , Kitchener , H C , Kitson , S J , Manchanda , R , McMahon , R F T , Monahan , K J , Menon , U , Møller , P , Möslein , G , Rosenthal , A , Sasieni , P ....

مصطلحات موضوعية: endometrial cancer, guidance, Lynch syndrome, screening, surveillance, /dk/atira/pure/subjectarea/asjc/2700/2716, name=Genetics(clinical)

الوصف: Purpose : There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 in order to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients. Methods : Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice. Results : Guidance was developed in four key areas: 1) whether women with gynecological cancer should be screened for Lynch syndrome and 2) how this should be done; 3) whether there was a role for gynecological surveillance in women with proven Lynch syndrome; and 4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer. Conclusion : This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/8c009082-0934-4cec-8a13-9e24961a18e9Test

الإتاحة: https://doi.org/10.1038/s41436-019-0489-yTest
https://discovery.dundee.ac.uk/en/publications/8c009082-0934-4cec-8a13-9e24961a18e9Test
https://discovery.dundee.ac.uk/ws/files/32158326/s41436_019_0489_y.pdfTest
http://www.scopus.com/inward/record.url?scp=85063624600&partnerID=8YFLogxKTest