المؤلفون: Kaczmarczyk, Artur P., Déclais, Anne-Cécile, Newton, Matthew D., Boulton, Simon J., Lilley, David M. J., Rueda, David S.

المصدر: Kaczmarczyk , A P , Déclais , A-C , Newton , M D , Boulton , S J , Lilley , D M J & Rueda , D S 2022 , ' Search and processing of Holliday junctions within long DNA by junction-resolving enzymes ' , Nature Communications , vol. 13 , 5921 . https://doi.org/10.1038/s41467-022-33503-6Test

مصطلحات موضوعية: DNA/metabolism, DNA, Cruciform, Deoxyribonuclease I/metabolism, Endodeoxyribonucleases/metabolism, Endonucleases/metabolism, Holliday Junction Resolvases/metabolism, Nucleic Acid Conformation, /dk/atira/pure/subjectarea/asjc/1000, name=General, /dk/atira/pure/subjectarea/asjc/3100/3100, name=General Physics and Astronomy, /dk/atira/pure/subjectarea/asjc/1600/1600, name=General Chemistry, /dk/atira/pure/subjectarea/asjc/1300/1300, name=General Biochemistry,Genetics and Molecular Biology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/d9a29e50-70ce-4f71-8000-0d02793bd0e6Test

الإتاحة: https://doi.org/10.1038/s41467-022-33503-6Test
https://discovery.dundee.ac.uk/en/publications/d9a29e50-70ce-4f71-8000-0d02793bd0e6Test
https://discovery.dundee.ac.uk/ws/files/87730471/s41467_022_33503_6.pdfTest
http://www.scopus.com/inward/record.url?scp=85139571965&partnerID=8YFLogxKTest

المؤلفون: Bueren-Calabuig, Juan, Bage, Marcus, Cowling, Victoria, Pisliakov, Andrei

المصدر: Bueren-Calabuig , J , Bage , M , Cowling , V & Pisliakov , A 2019 , ' Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM : Insights from accelerated molecular dynamics simulations ' , Nucleic Acids Research , vol. 47 , no. 16 , gkz613 , pp. 8675-8692 . https://doi.org/10.1093/nar/gkz613Test

مصطلحات موضوعية: RNMT, allosteric activation, accelerated molecular dynamics, conformational selection, mRNA cap, Allosteric Regulation, Humans, Substrate Specificity, RNA Caps/chemistry, Recombinant Proteins/chemistry, Thermodynamics, RNA Polymerase II/genetics, Methyltransferases/chemistry, S-Adenosylmethionine/chemistry, Cloning, Molecular, Transcription, Genetic, Protein Interaction Domains and Motifs, Binding Sites, Genetic Vectors/chemistry, Amino Acid Sequence, Protein Conformation, alpha-Helical, Gene Expression, RNA-Binding Proteins/chemistry, S-Adenosylhomocysteine/chemistry, Escherichia coli/genetics, Molecular Dynamics Simulation, Sequence Homology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/c67a2e6b-59db-400c-804f-6d913de05201Test

الإتاحة: https://doi.org/10.1093/nar/gkz613Test
https://discovery.dundee.ac.uk/en/publications/c67a2e6b-59db-400c-804f-6d913de05201Test
https://discovery.dundee.ac.uk/ws/files/36653182/gkz613.pdfTest
http://www.scopus.com/inward/record.url?scp=85073307093&partnerID=8YFLogxKTest

المؤلفون: Vickery, Owen, Carvalheda Dos Santos, Catarina, Zaidi, Saheem A., Pisliakov, Andrei, Katritch, Vsevolod, Zachariae, Ulrich

المصدر: Vickery , O , Carvalheda Dos Santos , C , Zaidi , S A , Pisliakov , A , Katritch , V & Zachariae , U 2018 , ' Intracellular Transfer of Na+ in an Active State G Protein Coupled Receptor ' , Structure , vol. 26 , no. 1 , pp. 171-180.e2 . https://doi.org/10.1016/j.str.2017.11.013Test

مصطلحات موضوعية: free energy profiles, GPCR, GPCR activation, ion channels, membrane surface receptors, pK, polar network, protonation state, signal transduction, sodium, Humans, Cations, Monovalent, Thermodynamics, Ion Transport, Protein Interaction Domains and Motifs, Binding Sites, Protein Conformation, alpha-Helical, Static Electricity, Molecular Dynamics Simulation, Amino Acid Motifs, Receptor, Muscarinic M2/chemistry, Sodium/chemistry, Carbachol/chemistry, Phosphatidylcholines/chemistry, Hydrophobic and Hydrophilic Interactions, Protein Binding, Ligands

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/cb2828ea-82fc-42c4-834f-e43545d90f81Test

الإتاحة: https://doi.org/10.1016/j.str.2017.11.013Test
https://discovery.dundee.ac.uk/en/publications/cb2828ea-82fc-42c4-834f-e43545d90f81Test
https://discovery.dundee.ac.uk/ws/files/41826641/Vickeryet_al_Final_submission_09_11.pdfTest
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805466Test/

المؤلفون: Shi, Xuesong, Huang, Lin, Lilley, David M. J., Harbury, Pehr B., Herschlag, Daniel

المصدر: Shi , X , Huang , L , Lilley , D M J , Harbury , P B & Herschlag , D 2016 , ' The solution structural ensembles of RNA kink-turn motifs and their protein complexes ' , Nature Chemical Biology , vol. 12 , no. 3 , pp. 146-152 . https://doi.org/10.1038/nchembio.1997Test

مصطلحات موضوعية: Base sequence, Interferometry, Molecular dynamics simulation, Molecular sequence data, Nucleic acid conformation, Nucleotide motifs, RNA, Scattering, Radiation, X-Rays, Journal article, Research support, N.I.H., Extramural, Non-U.S. Gov't

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/c9fd8da4-b54b-405e-b312-ea0026b53ea5Test

الإتاحة: https://doi.org/10.1038/nchembio.1997Test
https://discovery.dundee.ac.uk/en/publications/c9fd8da4-b54b-405e-b312-ea0026b53ea5Test
https://discovery.dundee.ac.uk/ws/files/9708336/main_text_LH_10_22_2105E.pdfTest

المؤلفون: Moynié, Lucile, Hope, Anthony G., Finzel, Kara, Schmidberger, Jason, Leckie, Stuart M., Schneider, Gunter, Burkart, Michael D., Smith, Andrew D., Gray, David W., Naismith, James H.

المصدر: Moynié , L , Hope , A G , Finzel , K , Schmidberger , J , Leckie , S M , Schneider , G , Burkart , M D , Smith , A D , Gray , D W & Naismith , J H 2016 , ' A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of Pseudomonas aeruginosa FabA ' , Journal of Molecular Biology , vol. 428 , no. 1 , pp. 108-120 . https://doi.org/10.1016/j.jmb.2015.10.027Test

مصطلحات موضوعية: Crystallography, X-Ray, Cysteamine, Enzyme Inhibitors, Escherichia coli, Fatty Acid Synthase, Type II, High-Throughput Screening Assays, Models, Molecular, Protein Conformation, Pseudomonas aeruginosa

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/e9dc0cc2-8783-4970-9944-5d05bc3b56c4Test

الإتاحة: https://doi.org/10.1016/j.jmb.2015.10.027Test
https://discovery.dundee.ac.uk/en/publications/e9dc0cc2-8783-4970-9944-5d05bc3b56c4Test
https://discovery.dundee.ac.uk/ws/files/9378432/1_s2.0_S002228361500621X_main.pdfTest

المؤلفون: O'Rourke, Patrick E. F., Kalinowska-Tłuścik, Justyna, Fyfe, Paul K., Dawson, Alice, Hunter, William N.

المصدر: O'Rourke , P E F , Kalinowska-Tłuścik , J , Fyfe , P K , Dawson , A & Hunter , W N 2014 , ' Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia : comparisons inform antimicrobial drug target assessment ' BMC Structural Biology , vol 14 , 1 . DOI:10.1186/1472-6807-14-1

مصطلحات موضوعية: Amino Acid Sequence, Burkholderia cenocepacia, Catalytic Domain, Citric Acid, Crystallography, X-Ray, Erythritol, Models, Molecular, Phosphorus-Oxygen Lyases, Plasmodium falciparum, Protein Conformation, Protein Structure, Secondary, Recombinant Proteins, Sequence Alignment, Substrate Specificity, Sugar Phosphates, Zinc

الإتاحة: https://doi.org/10.1186/1472-6807-14-1Test
http://discovery.dundee.ac.uk/portal/en/research/crystal-structures-of-ispf-from-plasmodium-falciparum-and-burkholderia-cenocepaciaTest(572de141-f602-433c-b294-fd7b39c87ab4).html
http://hdl.handle.net/10588/572de141-f602-433c-b294-fd7b39c87ab4Test

المؤلفون: Bowman, Lisa, Flanagan, Lindsey, Fyfe, Paul K., Parkin, Alison, Hunter, William N., Sargent, Frank

المصدر: Bowman , L , Flanagan , L , Fyfe , P K , Parkin , A , Hunter , W N & Sargent , F 2014 , ' How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase ' Biochemical Journal , vol 458 , no. 3 , pp. 449-458 . DOI:10.1042/BJ20131520

مصطلحات موضوعية: Bacterial Proteins, Catalysis, Crystallography, X-Ray, Genetic Engineering, Glutamic Acid, Histidine, Hydrogen, Hydrogenase, Oxygen, Protein Conformation, Protein Subunits, Salmonella enterica

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1042/BJ20131520Test
http://discovery.dundee.ac.uk/portal/en/research/how-the-structure-of-the-large-subunit-controls-function-in-an-oxygentolerant-nifehydrogenaseTest(ace6225e-a4ea-4187-8e6f-5771d9b2057f).html
http://hdl.handle.net/10588/ace6225e-a4ea-4187-8e6f-5771d9b2057fTest
http://discovery.dundee.ac.uk/ws/files/8021631/449.full_1_.pdfTest
http://www.biochemj.org/bjTest/

المؤلفون: Lucas, Xavier, Simon, Silke, Schubert, Rolf, Günther, Stefan

المصدر: Lucas , X , Simon , S , Schubert , R & Günther , S 2013 , ' Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies ' , PLoS ONE , vol. 8 , no. 4 , e60679 . https://doi.org/10.1371/journal.pone.0060679Test

مصطلحات موضوعية: Biological transport, Caco-2 cells, Cell line, Chemistry, Pharmaceutical, Cryoelectron microscopy, Digoxin, Drug discovery, Drug resistance, Multiple, Fluoresceins, Humans, Molecular docking simulation, P-Glycoproteins, Permeability, Phosphatidylinositols, Phospholipids, Protein binding, Protein conformation, Journal article, Research support, Non-U.S. Gov't

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/e17e9424-5420-47b0-bb5f-764362e56380Test

الإتاحة: https://doi.org/10.1371/journal.pone.0060679Test
https://discovery.dundee.ac.uk/en/publications/e17e9424-5420-47b0-bb5f-764362e56380Test
https://discovery.dundee.ac.uk/ws/files/10641939/journal.pone.0060679.PDFTest

المؤلفون: Dawson, Alice, Gibellini, Federica, Sienkiewicz, Natasha, Tulloch, Lindsay B., Fyfe, Paul K., McLuskey, Karen, Fairlamb, Alan H., Hunter, William N.

المصدر: Dawson , A , Gibellini , F , Sienkiewicz , N , Tulloch , L B , Fyfe , P K , McLuskey , K , Fairlamb , A H & Hunter , W N 2006 , ' Structure and reactivity of Trypanosoma brucei pteridine reductase : inhibition by the archetypal antifolate methotrexate ' , Molecular Microbiology , vol. 61 , no. 6 , pp. 1457-1468 . https://doi.org/10.1111/j.1365-2958.2006.05332.xTest

مصطلحات موضوعية: Amino Acid Sequence, Animals, Binding Sites, Catalytic Domain, Crystallography, X-Ray, Folic Acid Antagonists/pharmacology, Methotrexate/pharmacology, Molecular Sequence Data, Oxidoreductases/antagonists & inhibitors, Protein Conformation, Protozoan Proteins/antagonists & inhibitors, Trypanosoma brucei brucei/enzymology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/cc8f4567-cceb-43d7-aaf4-e3d0bc5b9641Test

الإتاحة: https://doi.org/10.1111/j.1365-2958.2006.05332.xTest
https://discovery.dundee.ac.uk/en/publications/cc8f4567-cceb-43d7-aaf4-e3d0bc5b9641Test
https://discovery.dundee.ac.uk/ws/files/35647144/Dawson_et_al_2006_Molecular_Microbiology.pdfTest

المؤلفون: Raghava, G P S, Barton, Geoffrey J

المصدر: Raghava , G P S & Barton , G J 2006 , ' Quantification of the variation in percentage identity for protein sequence alignments ' , BMC Bioinformatics , vol. 7 , pp. 415 . https://doi.org/10.1186/1471-2105-7-415Test

مصطلحات موضوعية: Algorithms, Amino Acid Sequence, Computational Biology, Databases, Protein, Protein Conformation, Proteins, Sequence Alignment, Software

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/fa19dec6-dab9-4e51-9af4-93b32caebb7aTest

الإتاحة: https://doi.org/10.1186/1471-2105-7-415Test
https://discovery.dundee.ac.uk/en/publications/fa19dec6-dab9-4e51-9af4-93b32caebb7aTest
https://discovery.dundee.ac.uk/ws/files/9223181/art_3A10.1186_2F1471_2105_7_415.pdfTest