دورية أكاديمية
TP53 codon 72 polymorphism and cervical cancer:a pooled analysis of individual data from 49 studies
| العنوان: | TP53 codon 72 polymorphism and cervical cancer:a pooled analysis of individual data from 49 studies |
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| المؤلفون: | Klug, Stefanie J., Ressing, Meike, Koenig, Jochem, Abba, Martin C., Agorastos, Theodoros, Brenna, Sylvia M. F., Ciotti, Marco, Das, B. R., Del Mistro, Annarosa, Dybikowska, Aleksandra, Giuliano, Anna R., Gudleviciene, Zivile, Gyllensten, Ulf, Haws, Andrea L. F., Helland, Aslaug, Herrington, C. Simon, Hildesheim, Alan, Humbey, Olivier, Jee, Sun H., Kim, Jae Weon, Madeleine, Margaret M., Menczer, Joseph, Ngan, Hextan Y. S., Nishikawa, Akira, Niwa, Yoshimitsu, Pegoraro, Rosemary, Pillai, M. R., Ranzani, Gulielmina, Rezza, Giovanni, Rosenthal, Adam N., Roychoudhury, Susanta, Saranath, Dhananjaya, Schmitt, Virginia M., Sengupta, Sharmila, Settheetham-Ishida, Wannapa, Shirasawa, Hiroshi, Snijders, Peter J. F., Stoler, Mark H., Suarez-Rincon, Angel E., Szarka, Krisztina, Tachezy, Ruth, Ueda, Masatsugu, van der Zee, Ate G. J., Doeberitz, Magnus von Knebel, Wu, Ming-Tsang, Yamashita, Tsuyoshi, Zehbe, Ingeborg, Blettner, Maria |
| المصدر: | Klug , S J , Ressing , M , Koenig , J , Abba , M C , Agorastos , T , Brenna , S M F , Ciotti , M , Das , B R , Del Mistro , A , Dybikowska , A , Giuliano , A R , Gudleviciene , Z , Gyllensten , U , Haws , A L F , Helland , A , Herrington , C S , Hildesheim , A , Humbey , O , Jee , S H , Kim , J W , Madeleine , M M , Menczer , .... |
| سنة النشر: | 2009 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | SQUAMOUS INTRAEPITHELIAL LESIONS, HUMAN-PAPILLOMAVIRUS TYPE-16, HARDY-WEINBERG EQUILIBRIUM, P53 ARG72PRO POLYMORPHISM, WILD-TYPE P53, HEALTHY WOMEN, HPV INFECTION, INDIAN WOMEN, RISK-FACTORS, GENOTYPES |
| الوصف: | Background Cervical cancer is caused primarily by human papillomaviruses (HPV). The polymorphism rs1042522 at codon 72 of the TP53 tumour-suppressor gene has been investigated as a genetic cofactor. More than 80 studies were done between 1998 and 2006, after it was initially reported that women who are homozygous for the arginine allele had a risk for cervical cancer seven times higher than women who were heterozygous for the allele. However, results have been inconsistent. Here we analyse pooled data from 49 studies to determine whether there is an association between TP53 codon 72 polymorphism and cervical cancer. Methods Individual data on 7946 cases and 7888 controls from 49 different studies worldwide were reanalysed. Odds ratios (OR) were estimated using logistic regression, stratifying by study and ethnic origin. Subgroup analyses were done for infection with HPV, ethnic origin, Hardy-Weinberg equilibrium, study quality, and the material used to determine TP53 genotype. Findings The pooled estimates (OR) for invasive cervical cancer were 1.22 (95% CI 1.08-1-39) for arginine homozygotes compared with heterozygotes, and 1.13 (0.94-1.35) for arginine homozygotes versus proline homozygotes. Subgroup analyses showed significant excess risks only in studies where controls were not in Hardy-Weinberg equilibrium (1.71 [1.21-2.42] for arginine homozygotes compared with heterozygotes), in non-epidemiological studies (1.35 [1.15-1.58] for arginine homozygotes compared with heterozygotes), and in studies where TP53 genotype was determined from tumour tissue (1.39 [1.13-1.73] for arginine homozygotes compared with heterozygotes). Null results were noted in studies with sound epidemiological design and conduct (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes), and studies in which TP53 genotype was determined from white blood cells (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes). Interpretation Subgroup analyses indicated that excess risks were most likely not due to ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://discovery.dundee.ac.uk/en/publications/5fa0f701-d0e5-405b-a64a-8db1eeef28d6Test |
| DOI: | 10.1016/S1470-2045(09)70187-1 |
| الإتاحة: | https://doi.org/10.1016/S1470-2045Test(09)70187-1 https://discovery.dundee.ac.uk/en/publications/5fa0f701-d0e5-405b-a64a-8db1eeef28d6Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.40CE9B67 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S1470-2045(09)70187-1 |
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