دورية أكاديمية
Thrombin generation and factor VIII:C levels in patients with type 1 diabetes complicated by nephropathy
| العنوان: | Thrombin generation and factor VIII:C levels in patients with type 1 diabetes complicated by nephropathy |
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| المؤلفون: | Ibbotson, S H, Rayner, H, Stickland, M H, Davies, J A, Grant, P J |
| المصدر: | Ibbotson , S H , Rayner , H , Stickland , M H , Davies , J A & Grant , P J 1993 , ' Thrombin generation and factor VIII:C levels in patients with type 1 diabetes complicated by nephropathy ' , Diabetic Medicine , vol. 10 , no. 4 , pp. 336-340 . https://doi.org/10.1111/j.1464-5491.1993.tb00075.xTest |
| سنة النشر: | 1993 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Thrombin, Reference Values, Albuminuria, Diabetic Nephropathies, Blood Pressure, Humans, Cholesterol, Factor VIII, Diabetic Retinopathy, Diabetes Mellitus, Type 1, Triglycerides, Adult, Middle Aged, Female, Male |
| الوصف: | The association between plasma coagulant activity and the presence of diabetic nephropathy was investigated in 31 patients with Type 1 diabetes, 12 with and 19 without nephropathy, and in 11 healthy subjects. Thrombin generation was assessed by computer assisted chromogenic method and expressed as time (in seconds) to 50% maximal thrombin activity (T 50 ). Factor VIII:C levels related to thrombin activity, glycaemic control, and renal function. Median (IQ) FVIII:C concentration was increased in patients with nephropathy (1590 (1130-1900) IU l -1 ) compared to those without renal disease and with controls (960 (750-1090); 1020 (810-1100) IU l -1 , p <0.01, respectively). There were no significant differences in T50 values between the groups. FVIII:C correlated with age in all subjects and in the diabetic group (r = 0.33, p = 0.036; r = 0.39, p = 0.031) and inversely with T 50 in all subjects and in controls (r = -0.35, p = 0.02; r = -0.62, p = 0.04). In all subjects and in patients, FVIII:C was related to urinary albumin excretion and creatinine clearance. FVIII:C and T 50 were not related to HbA 1c . The results show that FVIII:C levels are increased in Type 1 diabetes complicated by nephropathy and are related to degree of renal impairment but not levels of glycaemia. No associated enhancement of plasma procoagulant activity was detected. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://discovery.dundee.ac.uk/en/publications/7b6a26b4-dbdd-47dd-a289-74f6f66b671eTest |
| DOI: | 10.1111/j.1464-5491.1993.tb00075.x |
| الإتاحة: | https://doi.org/10.1111/j.1464-5491.1993.tb00075.xTest https://discovery.dundee.ac.uk/en/publications/7b6a26b4-dbdd-47dd-a289-74f6f66b671eTest |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.8A31FAF0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1464-5491.1993.tb00075.x |
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