دورية أكاديمية
Fear extinction is regulated by the activity of long noncoding RNAs at the synapse
| العنوان: | Fear extinction is regulated by the activity of long noncoding RNAs at the synapse |
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| المؤلفون: | Liau, Wei Siang, Zhao, Qiongyi, Bademosi, Adekunle, Gormal, Rachel S., Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Madugalle, Sachithrani U., Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason, Davies, Joshua, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Li, Xiang, Wei, Wei, Meunier, Frédéric A., Fernández Moya, Sandra M., Kiebler, Michael A., Srinivasan, Balakumar, Banerjee, Sourav, Clark, Michael, Spitale, Robert C., Bredy, Timothy W. |
| المصدر: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Escorça frontal, Sinapsi, Prefrontal Cortex, Synapses |
| الوصف: | Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for their activity in this subcellular compartment in memory formation has yet to be demonstrated. Using lncRNA capture-seq, we identified a specific set of lncRNAs that accumulate in the synaptic compartment within the infralimbic prefrontal cortex of adult male C57/Bl6 mice. Among these was a splice variant related to the stress-associated lncRNA, Gas5. RNA immunoprecipitation followed by mass spectrometry and single-molecule imaging revealed that this Gas5 isoform, in association with the RNA binding proteins G3BP2 and CAPRIN1, regulates the activity-dependent trafficking and clustering of RNA granules. In addition, we found that cell-type-specific, activity-dependent, and synapse-specific knockdown of the Gas5 variant led to impaired fear extinction memory. These findings identify a new mechanism of fear extinction that involves the dynamic interaction between local lncRNA activity and RNA condensates in the synaptic compartment. Synaptic activity controls the extinction of conditioned fear. Here the authors discovered a new way that the brain controls memories of fear: a long noncoding RNA called Gas5 that coordinates the activity of RNA granules in the synaptic compartment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 16 p.; application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-023-43535-1Test; Nature Communications, 2023, vol. 14, num. 1; https://doi.org/10.1038/s41467-023-43535-1Test; http://hdl.handle.net/2445/206244Test |
| الإتاحة: | https://doi.org/10.1038/s41467-023-43535-1Test http://hdl.handle.net/2445/206244Test |
| حقوق: | cc by (c) Liau, Wei Siang et al., 2023 ; http://creativecommons.org/licenses/by/3.0/esTest/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3D292CC6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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