المؤلفون: Tursi, Antonio, Brandimarte, Giovanni, Mario, Francesco Di, Lanas, Angel, Scarpignato, Carmelo, Bafutto, Mauro, Barbara, Giovanni, Bassotti, Gabrio, Binda, Gian Andrea, Biondi, Alberto, Biondo, Sebastián, Cassieri, Claudio, Crucitti, Antonio, Dumitrascu, Dan L., Elisei, Walter, Escalante, Ricardo, Herszenyi, László, Kruis, Wolfgang, Kupcinskas, Juozas, Lahat, Adi, Lecca, Piera G., Maconi, Giovanni, Malfertheiner, Peter, Mazzarri, Andrea, Mearin, Fermín, 1956-, Milosavljeviċ, Tomica, Nardone, Gerardo, Chavez de Oliveira, Enio, Papa, Alfredo, Papagrigoriadis, Savvas, Pera Román, Miguel, Persiani, Roberto, Picchio, Marcello, Regula, Jaroslaw, Štimac, Davor, Stollman, Neil, Strate, Lisa L.

المصدر: Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

مصطلحات موضوعية: Malalties del còlon, Colonoscòpia, Colonic diseases, Colonoscopy

الوصف: Background & Aims: The Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification of diverticulosis and diverticular disease (DD) is currently available. It scores severity of the disease as DICA 1, DICA 2 and DICA 3. Our aim was to assess the agreement on this classification in an international endoscopists community setting. Methods: A total of 96 doctors (82.9% endoscopists) independently scored a set of DD endoscopic videos. The percentages of overall agreement on DICA score and a free-marginal multirater kappa (kappa) coefficient were reported as statistical measures of interrater agreement. Results: Overall agreement in using DICA was 91.8% with a free-marginal kappa of 88% (95% CI 80-95). The overall agreement levels were: DICA 1, 85.2%; DICA 2, 96.5%; DICA 3, 99.5%. The free marginal. was: DICA 1 = 0.753, DICA 2 = 0.958, DICA 3 = 0.919. The agreement about the main endoscopic items was 83.4% (k 67%) for diverticular extension, 62.6% (k 65%) for number of diverticula for each district, 86.8% (k 82%) for presence of inflammation, and 98.5 (k 98%) for presence of complications. Conclusions: The overall interrater agreement in this study ranges from good to very good. DICA score is a simple and reproducible endoscopic scoring system for diverticulosis and DD.

وصف الملف: 5 p.; application/pdf

العلاقة: Reproducció del document publicat a: https://doi.org/10.15403/jgld-558Test; Journal of Gastrointestinal and Liver Diseases, 2019, vol. 28, p. 39-43; https://doi.org/10.15403/jgld-558Test; http://hdl.handle.net/2445/171636Test

الإتاحة: https://doi.org/10.15403/jgld-558Test
http://hdl.handle.net/2445/171636Test

المؤلفون: Tursi, Antonio, Brandimarte, Giovanni, Di Mario, Francesco, Lanas, Angel, Scarpignato, Carmelo, Bafutto, Mauro, Barbara, Giovanni, Bassotti, Gabrio, Binda, Gian Andrea, Biondi, Alberto, Biondo, Sebastián, Cambiè, Ginevra, Cassieri, Claudio, Crucitti, Antonio, Dumitrascu, Dan L., Elisei, Walter, Escalante, Ricardo, Herszènyi, László, Kruis, Wolfgang, Kupcinskas, Juozas, Lahat, Adi, Lecca, Piera G., Maconi, Giovanni, Malfertheiner, Peter, Mazzari, Andrea, Mearin, Fermín, 1956-, Milosavljeviċ, Tomica, Nardone, Gerardo, Chavez De Oliveira, Enio, Papa, Alfredo, Papagrigoriadis, Savvas, Pera Román, Miguel, Persiani, Robero, Picchio, Marcello, Regula, Jaroslaw, Timac, Davor, Stollman, Neil, Strate, Lisa L., Violi, Alessandra, Walker, Marjorie M.D.

المصدر: Articles publicats en revistes (Ciències Clíniques)

مصطلحات موضوعية: Etiologia, Terapèutica, Malalties inflamatòries intestinals, Etiology, Therapeutics, Inflammatory bowel diseases

الوصف: The statements produced by the Chairmen and Speakers of the 3rd International Symposium on Diverticular Disease, held in Madrid on April 11th-13th 2019, are reported. Topics such as current and evolving concepts on the pathogenesis, the course of the disease, the news in diagnosing, hot topics in medical and surgical treatments, and finally, critical issues on the disease were reviewed by the Chairmen who proposed 39 statements graded according to level of evidence and strength of recommendation. Each topic was explored focusing on the more relevant clinical questions. The vote was conducted on a 6-point scale and consensus was defined a priori as 67% agreement of the participants. The voting group consisted of 124 physicians from 18 countries, and agreement with all statements was provided. Comments were added explaining some controversial areas.

وصف الملف: 10 p.; application/pdf

العلاقة: Reproducció del document publicat a: https://doi.org/10.15403/jgld-562Test; Journal of Gastrointestinal and Liver Diseases, 2019, vol. 28, p. 57-66; https://doi.org/10.15403/jgld-562Test; http://hdl.handle.net/2445/165667Test; 698043

الإتاحة: https://doi.org/10.15403/jgld-562Test
http://hdl.handle.net/2445/165667Test

المؤلفون: Chertow, Jessica H, Alkaitis, Matthew S, Nardone, Glenn, Ikeda, Allison K, Cunnington, Aubrey J, Okebe, Joseph, Ebonyi, Augustine O, Njie, Madi, Correa, Simon, Jayasooriya, Shamanthi, Casals Pascual, Climent, Bilker, Oliver, Conway, David J., Walther, Michael, Ackerman, Hans

المصدر: Articles publicats en revistes (Fonaments Clínics)

مصطلحات موضوعية: Malària, Plasma sanguini, Homeòstasi, Malaria, Blood plasma, Homeostasis

الوصف: Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an endogenous NO synthase (NOS) inhibitor, and arginine, the NOS substrate. We carried out a community-based case-control study of Gambian children to determine whether ADMA and arginine homeostasis is disrupted during severe or uncomplicated malaria infections. Circulating plasma levels of ADMA and arginine were determined at initial presentation and 28 days later. Plasma ADMA/arginine ratios were elevated in children with acute severe malaria compared to 28-day follow-up values and compared to children with uncomplicated malaria or healthy children (p<0.0001 for each comparison). To test the hypothesis that DDAH1 is inactivated during Plasmodium infection, we examined DDAH1 in a mouse model of severe malaria. Plasmodium berghei ANKA infection inactivated hepatic DDAH1 via a post-transcriptional mechanism as evidenced by stable mRNA transcript number, decreased DDAH1 protein concentration, decreased enzyme activity, elevated tissue ADMA, elevated ADMA/arginine ratio in plasma, and decreased whole blood nitrite concentration. Loss of hepatic DDAH1 activity and disruption of ADMA/arginine homeostasis may contribute to severe malaria pathogenesis by inhibiting NO synthesis

وصف الملف: 20 p.; application/pdf

العلاقة: Reproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1005119Test; PLoS Pathogens, 2015, vol. 11, num. 9:e1005119; https://doi.org/10.1371/journal.ppat.1005119Test; http://hdl.handle.net/2445/112099Test; 670563

الإتاحة: https://doi.org/10.1371/journal.ppat.1005119Test
http://hdl.handle.net/2445/112099Test